294190-18-4

Usage

Uses

Used in Pharmaceutical Industry:
Benzoic acid, 3-amino-5-chloro-2-methyl-, methyl ester is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be chemically modified and incorporated into drug molecules. Its antimicrobial and antifungal properties also make it a potential candidate for the development of new antimicrobial agents to combat drug-resistant infections.
Used in Agrochemical Industry:
In the agrochemical industry, Benzoic acid, 3-amino-5-chloro-2-methyl-, methyl ester is utilized as an intermediate in the production of pesticides and other agrochemicals. Its antimicrobial properties can be harnessed to develop new compounds that protect crops from diseases and pests, thereby increasing agricultural productivity.
Used in Industrial Applications:
Benzoic acid, 3-amino-5-chloro-2-methyl-, methyl ester can be used in various industrial applications, such as in the manufacturing of plastics, resins, and other polymers. Its chemical properties allow it to be incorporated into these materials to enhance their performance characteristics, such as durability, stability, and resistance to microbial degradation.
It is important to handle Benzoic acid, 3-amino-5-chloro-2-methyl-, methyl ester with care, as it may have potential hazards if not used properly. Proper safety measures should be taken during its synthesis, storage, and application to minimize any risks associated with its use.

Upstream product

• 294190-17-3 methyl 5-chloro-2-methyl-3-nitrobenzoate 
• 154257-81-5 5-chloro-2-methyl-3-nitrobenzoic acid 
• 7499-06-1 5-chloro-2-methylbenzoic acid 

Downstream Products

• 1403597-77-2 methyl 3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)amino)-5-chloro-2-methylbenzoate 
• 1403597-67-0 methyl 3-(((cis)-4-((tert-butoxycarbonyl)amino)cyclohexyl)amino)-5-chloro-2-methylbenzoate 
• 1403596-70-2 methyl 5-chloro-3-(cyclobutylamino)-2-methylbenzoate 
• 1403596-75-7 methyl 5-chloro-2-methyl-3-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzoate 
• 1403595-92-5 methyl 5-chloro-3-(cycloheptylamino)-2-methylbenzoate 
• 1403595-77-6 methyl 5-chloro-3-(cyclopentanecarboxamido)-2-methylbenzoate 
• 1403595-38-9 methyl 5-chloro-3-(cyclohexylamino)-2-methylbenzoate 
• 1403595-50-5 methyl 5-chloro-2-methyl-3-((tetrahydro-2H-pyran-4-yl)amino)benzoate 
• 1403596-65-5 methyl 5-chloro-3-((cyclopentylmethyl)amino)-2-methylbenzoate 
• 1403595-31-2 tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)-amino)-piperidine-1-carboxylate 
• 1403596-60-0 methyl 5-chloro-3-(isobutylamino)-2-methylbenzoate 
• 1403590-52-2 5-chloro-3-(cyclohexyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide 
• 1403595-39-0 methyl 5-chloro-3-(cyclohexyl(methyl)amino)-2-methylbenzoate 
• 1403595-40-3 C₁₅H₂₀ClNO₂ 

Relevant academic research and scientific papers

The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat

Posttranslational methylation of histones plays a critical role in gene regulation. Misregulation of histone methylation can lead to oncogenic transformation. Enhancer of Zeste homologue 2 (EZH2) methylates histone 3 at lysine 27 (H3K27) and abnormal methylation of this site is found in many cancers. Tazemetostat, an EHZ2 inhibitor in clinical development, has shown activity in both preclinical models of cancer as well as in patients with lymphoma or INI1-deficient solid tumors. Herein we report the structure-activity relationships from identification of an initial hit in a high-throughput screen through selection of tazemetostat for clinical development. The importance of several methyl groups to the potency of the inhibitors is highlighted as well as the importance of balancing pharmacokinetic properties with potency.

ENHANCER OF ZESTE HOMOLOG 2 INHIBITORS

This invention relates to novel substituted benzamide according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

SUBSTITUTED BENZENE COMPOUNDS

The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.