1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarboxylic acid

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Chemical Name:1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarboxylic acid
CAS No.:1352713-63-3
Molecular Formula:C₄₄H₄₃ClO₇
Molecular Weight:719.274
Hs Code.:

Synonyms:1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarboxylic acid

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Chemical Property of 1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarboxylic acid

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Technology Process of 1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarboxylic acid

There total 4 articles about 1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1352713-62-2
1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarbonitrile

: 1352713-63-3
1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarboxylic acid

Guidance literature:: 1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarbonitrile; With water; sodium hydroxide; In ethanol; at 110 ℃; for 15h;

With hydrogenchloride; In water; at 0 ℃;

Reference yield:

: 1225430-37-4
(2-chloro-5-((3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methanol

: 1352713-63-3
1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; phosphorus tribromide / diethyl ether / 16 h / 0 °C / Reflux; Inert atmosphere

2.1: ethanol; water / 15 h / Reflux

3.1: sodium hydroxide / tetrabutylammomium bromide / toluene; water / 15 h / 20 °C

4.1: sodium hydroxide; water / ethanol / 15 h / 110 °C

4.2: 0 °C

With pyridine; water; phosphorus tribromide; sodium hydroxide; tetrabutylammomium bromide; In diethyl ether; ethanol; water; toluene;

Reference yield:

: 1260242-00-9
(2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-(benzyloxymethyl)-6-(3-(bromomethyl)-4-chlorophenyl)-tetrahydro-2H-pyran

: 1352713-63-3
1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol; water / 15 h / Reflux

2.1: sodium hydroxide / tetrabutylammomium bromide / toluene; water / 15 h / 20 °C

3.1: sodium hydroxide; water / ethanol / 15 h / 110 °C

3.2: 0 °C

With water; sodium hydroxide; tetrabutylammomium bromide; In ethanol; water; toluene;