1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarbonitrile

Base Information

Chemical Name:1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarbonitrile
CAS No.:1352713-62-2
Molecular Formula:C₄₄H₄₂ClNO₅
Molecular Weight:700.274
Hs Code.:

Synonyms:1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarbonitrile

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Chemical Property of 1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarbonitrile

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Technology Process of 1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarbonitrile

There total 3 articles about 1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1225430-39-6
2-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)acetonitrile

: 106-93-4
ethylene dibromide

: 1352713-62-2
1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarbonitrile

Guidance literature:: With sodium hydroxide; tetrabutylammomium bromide; In water; toluene; at 20 ℃; for 15h;

Reference yield:

: 1225430-37-4
(2-chloro-5-((3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methanol

: 1352713-62-2
1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; phosphorus tribromide / diethyl ether / 16 h / 0 °C / Reflux; Inert atmosphere

2: ethanol; water / 15 h / Reflux

3: sodium hydroxide / tetrabutylammomium bromide / toluene; water / 15 h / 20 °C

With pyridine; phosphorus tribromide; sodium hydroxide; tetrabutylammomium bromide; In diethyl ether; ethanol; water; toluene;

Reference yield:

: 1260242-00-9
(2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-(benzyloxymethyl)-6-(3-(bromomethyl)-4-chlorophenyl)-tetrahydro-2H-pyran

: 1352713-62-2
1-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)cyclopropanecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol; water / 15 h / Reflux

2: sodium hydroxide / tetrabutylammomium bromide / toluene; water / 15 h / 20 °C

With sodium hydroxide; tetrabutylammomium bromide; In ethanol; water; toluene;