7-benzyloxy-6-methoxy-1-methylene-2-nicotinyl-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 7-benzyloxy-6-methoxy-1-methylene-2-nicotinyl-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 120155-05-7
• Molecular Formula: C₂₄H₂₂N₂O₃
• Molecular Weight: 386.45
• Mol file: 120155-05-7.mol

Synonyms:7-benzyloxy-6-methoxy-1-methylene-2-nicotinyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 7-benzyloxy-6-methoxy-1-methylene-2-nicotinyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-benzyloxy-6-methoxy-1-methylene-2-nicotinyl-1,2,3,4-tetrahydroisoquinoline

There total 2 articles about 7-benzyloxy-6-methoxy-1-methylene-2-nicotinyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-pyridinecarbonyl chloride (10400-19-8) + 7-(benzyloxy)-6-methoxy-1-methyl-3,4-dihydroisoquinoline (78867-50-2) → 7-benzyloxy-6-methoxy-1-methylene-2-nicotinyl-1,2,3,4-tetrahydroisoquinoline (120155-05-7)

Guidance literature:

With triethylamine; In benzene; Ambient temperature;

DOI:10.1016/S0040-4020(01)85978-0

Reference yield:

sodium nicotinate (54-86-4) → 7-benzyloxy-6-methoxy-1-methylene-2-nicotinyl-1,2,3,4-tetrahydroisoquinoline (120155-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / benzene / 1 h / Heating

2: 76 percent / triethylamine / benzene / Ambient temperature

With oxalyl dichloride; triethylamine; In benzene;

DOI:10.1016/S0040-4020(01)85978-0

Reference yield: 27.0%

7-benzyloxy-6-methoxy-1-methylene-2-nicotinyl-1,2,3,4-tetrahydroisoquinoline (120155-05-7) → 11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzopyrido<3,2-g>quinolizin-5-one (120155-02-4) + 11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzopyrido<3,4-g>quinolizin-5-one (104669-20-7)

Guidance literature:

In benzene; at 15 - 20 ℃; for 4.5h; Irradiation;

DOI:10.1016/S0040-4020(01)85978-0

upstream raw materials:

3-pyridinecarbonyl chloride

7-(benzyloxy)-6-methoxy-1-methyl-3,4-dihydroisoquinoline

sodium nicotinate

Downstream raw materials:

11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzopyrido<3,2-g>quinolizin-5-one

11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzopyrido<3,4-g>quinolizin-5-one

11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzopyrido<3,4-g>quinolizin-5-thione