SODIUM NICOTINATE

Base Information

• Chemical Name: SODIUM NICOTINATE
• CAS No.: 54-86-4
• Molecular Formula: C6H5 N O2 . Na
• Molecular Weight: 145.093
• Hs Code.: 2933399090
• Mol file: 54-86-4.mol

Synonyms:3-Pyridinecarboxylicacid, sodium salt (9CI); Nicotinic acid, sodium salt (8CI); Naotin; Nicoside;Sodium nicotinate; Sodium pyridine-3-carboxylate

Chemical Property of SODIUM NICOTINATE

Chemical Property:

• Appearance/Colour: Cristalline powder
• Vapor Pressure: 0.000836mmHg at 25°C
• Melting Point: 236.6ºC
• Boiling Point: 292.5°Cat760mmHg
• Flash Point: 130.7°C
• PSA: 53.02000
• Density: 1.293g/cm³
• LogP: -0.55490

Purity/Quality:

98%,99%, ^*data from raw suppliers

Sodium Nicotinate >98.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Sodium nicotinate is an intermediate for the cosmetic and the pharmaceutical industry. Product Data Sheet

Technology Process of SODIUM NICOTINATE

There total 4 articles about SODIUM NICOTINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

nicotinic acid (59-67-6) → sodium nicotinate (54-86-4)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 0.5h;

DOI:10.1039/d0nj00753f

Reference yield:

nicotinyl hydroxamic acid (5657-61-4) → sodium nicotinate (54-86-4)

Guidance literature:

With potassium hexacyanoferrate(III); In aq. phosphate buffer; at 20 ℃; for 322h; pH=7.4; Solvent; Time;

DOI:10.1039/d0nj00753f

Reference yield:

methyl 3-pyridinecarboxylate (93-60-7) → methanol (67-56-1) + sodium nicotinate (54-86-4)

Guidance literature:

With sodium hydroxide; In water; dimethyl sulfoxide; at 20 ℃; Kinetics; Thermodynamic data; E_expt, ΔH(excit.), ΔS(excit.), ΔG; var. temp., var. H2O/DMSO mixtures;

upstream raw materials:

methyl 3-pyridinecarboxylate

nicotinic acid

nicotinyl hydroxamic acid

Downstream raw materials:

benzyl nicotinate

copper(II) nicotinate

C₁₉H₁₅N₅O₃S

n-propyl nicotinate

Refernces

• 1、 Carvalho, Edinilton Muniz,Rechignat, Lionel,Sousa, Eduardo Henrique Silva De,Lopes, Luiz Gonzaga De Fran?a,Chauvin, Remi,Bernardes-Génisson, Vania. "Mechanistic insights into the: In vitro metal-promoted oxidation of (di)azine hydroxamic acids: Evidence of HNO release and N, O -di(di)azinoyl hydroxylamine intermediate". supporting information. p. 11965 - 11973. Retrieved 2020/07/30.
• 2、 Sinha,Singh,Verma,Manjul,Singh. "A kinetic study of alkaline hydrolysis of methyl nicotinate in aquo-DMSO system conductometrically". . p. 463 - 465. Retrieved 2007/10/02.