5-[(Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amino)-methyl]-2,4-dihydro-[1,2,4]triazol-3-one

Base Information

Chemical Name:5-[(Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amino)-methyl]-2,4-dihydro-[1,2,4]triazol-3-one
CAS No.:606929-61-7
Molecular Formula:C₃₁H₃₀F₆N₄O₂
Molecular Weight:604.595
Hs Code.:

Synonyms:5-[(Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amino)-methyl]-2,4-dihydro-[1,2,4]triazol-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[(Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amino)-methyl]-2,4-dihydro-[1,2,4]triazol-3-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-[(Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amino)-methyl]-2,4-dihydro-[1,2,4]triazol-3-one

There total 7 articles about 5-[(Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amino)-methyl]-2,4-dihydro-[1,2,4]triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 606929-58-2
Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amine

: 252742-72-6
3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

: 606929-61-7
5-[(Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amino)-methyl]-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 ℃; for 9h;
DOI:10.1016/j.bmcl.2006.04.031

Reference yield:

: 530441-99-7
2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethanone

: 606929-61-7
5-[(Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amino)-methyl]-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / NaNH₂ / tetrahydrofuran / 24 h / 20 °C

2: 86 percent / Zn-Cu / diethyl ether; 1,2-dimethoxy-ethane / 120 h / Heating

3: Zn dust; AcOH / 48 h / 20 °C

4: 94 percent / NaBH(OAc)3 / 24 h / 20 °C

5: 77 percent / K₂CO₃ / dimethylformamide / 9 h / 0 °C

With sodium tris(acetoxy)borohydride; copper; potassium carbonate; sodium amide; acetic acid; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; N,N-dimethyl-formamide; 1: Wittig reaction;
DOI:10.1016/j.bmcl.2006.04.031

Reference yield:

: 606137-78-4
1-[(R)-1-(2-Phenyl-allyloxy)-ethyl]-3,5-bis-trifluoromethyl-benzene

: 606929-61-7
5-[(Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amino)-methyl]-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / Zn-Cu / diethyl ether; 1,2-dimethoxy-ethane / 120 h / Heating

2: Zn dust; AcOH / 48 h / 20 °C

3: 94 percent / NaBH(OAc)3 / 24 h / 20 °C

4: 77 percent / K₂CO₃ / dimethylformamide / 9 h / 0 °C

With sodium tris(acetoxy)borohydride; copper; potassium carbonate; acetic acid; zinc; In 1,2-dimethoxyethane; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.04.031