3-cyclopropyl-6,7-dimethoxy-1-[4-(2-methoxy-phenyl)-piperazin-1-yl]-isoquinoline

Base Information

Chemical Name:3-cyclopropyl-6,7-dimethoxy-1-[4-(2-methoxy-phenyl)-piperazin-1-yl]-isoquinoline
CAS No.:1616295-10-3
Molecular Formula:C₂₅H₂₉N₃O₃
Molecular Weight:419.524
Hs Code.:

Synonyms:3-cyclopropyl-6,7-dimethoxy-1-[4-(2-methoxy-phenyl)-piperazin-1-yl]-isoquinoline

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Chemical Property of 3-cyclopropyl-6,7-dimethoxy-1-[4-(2-methoxy-phenyl)-piperazin-1-yl]-isoquinoline

Chemical Property:

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Technology Process of 3-cyclopropyl-6,7-dimethoxy-1-[4-(2-methoxy-phenyl)-piperazin-1-yl]-isoquinoline

There total 5 articles about 3-cyclopropyl-6,7-dimethoxy-1-[4-(2-methoxy-phenyl)-piperazin-1-yl]-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1616296-09-3
C₂₂H₂₄ClN₃O₃

: 411235-57-9
cyclopropylboronic acid

: 1616295-10-3
3-cyclopropyl-6,7-dimethoxy-1-[4-(2-methoxy-phenyl)-piperazin-1-yl]-isoquinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; In toluene; at 110 ℃; Inert atmosphere;

Reference yield:

: 2107-69-9
5,6-dimethoxy-1-indanone

: 1616295-10-3
3-cyclopropyl-6,7-dimethoxy-1-[4-(2-methoxy-phenyl)-piperazin-1-yl]-isoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 1-nitrobutane; hydrogenchloride / methanol / 3 h / 40 °C

2: phosphorus pentachloride; trichlorophosphate / 2 h / 0 - 30 °C

3: pyridine / dichloromethane / 0 - 20 °C

4: N,N-dimethyl-formamide / 70 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate / toluene / 110 °C / Inert atmosphere

With pyridine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-nitrobutane; phosphorus pentachloride; potassium tert-butylate; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 2107-85-9
5,6-dimethoxy-indan-1,2-dione-2-oxime

: 1616295-10-3
3-cyclopropyl-6,7-dimethoxy-1-[4-(2-methoxy-phenyl)-piperazin-1-yl]-isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus pentachloride; trichlorophosphate / 2 h / 0 - 30 °C

2: pyridine / dichloromethane / 0 - 20 °C

3: N,N-dimethyl-formamide / 70 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate / toluene / 110 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus pentachloride; potassium tert-butylate; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide; toluene;