{4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]phenyl}methanolhexadeuterate

Base Information

• Chemical Name: {4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]phenyl}methanolhexadeuterate
• CAS No.: 863888-44-2
• Molecular Formula: C₁₆H₂₈O₃Si
• Molecular Weight: 302.434

Synonyms:{4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]phenyl}methanolhexadeuterate

Chemical Property of {4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]phenyl}methanolhexadeuterate

Chemical Property:

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Technology Process of {4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]phenyl}methanolhexadeuterate

There total 2 articles about {4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]phenyl}methanolhexadeuterate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]benzoic acid methyl ester tetradeuterate (863888-43-1) → {4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]phenyl}methanolhexadeuterate (863888-44-2)

Guidance literature:

4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]benzoic acid methyl ester tetradeuterate; With lithium aluminium deuteride; In tetrahydrofuran; at 0 - 20 ℃; for 3.5h;

With water; In tetrahydrofuran;

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → {4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]phenyl}methanolhexadeuterate (863888-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

2: lithium aluminium deuteride / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere

With 1H-imidazole; lithium aluminium deuteride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield: 66.0%

{4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]phenyl}methanolhexadeuterate (863888-44-2) + 2-tert-butyl-4-chloro-5-hydroxy-3(2H)-pyridazinone (88093-48-5) → 2-tert-butyl-4-chloro-5-{4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]benzyloxy}-2H-pyridazin-3-onehexadeuterate

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

upstream raw materials:

4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]benzoic acid methyl ester tetradeuterate

tert-butyldimethylsilyl chloride

Downstream raw materials:

toluene-4-sulfonic acid 2-[4-(1-tert-butyl-5-chloro-6-oxo-1,6-dihydro-pyridazin-4-yloxymethyl)-benzyloxy]ethyl esterhexadeuterate

toluene-4-sulfonic acid 2-[4-(1-tertbutyl-5-chloro-6-oxo-1,6-dihydropyridazin-4-yloxymethyl)benzyloxy] ethyl ester hexadeuterate

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