(3S,7R)-9-(tert-butyldiphenylsilyloxy)-3,7-dimethyl-6-(triethylsilyloxy)nonan-1-ol

Base Information

• Chemical Name: (3S,7R)-9-(tert-butyldiphenylsilyloxy)-3,7-dimethyl-6-(triethylsilyloxy)nonan-1-ol
• CAS No.: 1255910-60-1
• Molecular Formula: C₃₃H₅₆O₃Si₂
• Molecular Weight: 556.977
• Mol file: 1255910-60-1.mol

Synonyms:(3S,7R)-9-(tert-butyldiphenylsilyloxy)-3,7-dimethyl-6-(triethylsilyloxy)nonan-1-ol

Chemical Property of (3S,7R)-9-(tert-butyldiphenylsilyloxy)-3,7-dimethyl-6-(triethylsilyloxy)nonan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,7R)-9-(tert-butyldiphenylsilyloxy)-3,7-dimethyl-6-(triethylsilyloxy)nonan-1-ol

There total 1 articles about (3S,7R)-9-(tert-butyldiphenylsilyloxy)-3,7-dimethyl-6-(triethylsilyloxy)nonan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl (3S,7R)-9-(tert-butyldiphenylsilyloxy)-3,7-dimethyl-6-(triethylsilyloxy)nonanoate (1255910-59-8) → (3S,7R)-9-(tert-butyldiphenylsilyloxy)-3,7-dimethyl-6-(triethylsilyloxy)nonan-1-ol (1255910-60-1)

Guidance literature:

With diisobutylaluminium hydride; In n-heptane; dichloromethane; at -20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol102177j

Reference yield: 70.0%

(3S,7R)-9-(tert-butyldiphenylsilyloxy)-3,7-dimethyl-6-(triethylsilyloxy)nonan-1-ol (1255910-60-1) + Methyltriphenylphosphonium bromide (1779-49-3) → (7R)-10,10-diethyl-2,2,7-trimethyl-8-((S)-3-methylhex-5-enyl)-3,3-diphenyl-4,9-dioxa-3,10-disiladodecane (1255910-53-2)

Guidance literature:

(3S,7R)-9-(tert-butyldiphenylsilyloxy)-3,7-dimethyl-6-(triethylsilyloxy)nonan-1-ol; With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Methyltriphenylphosphonium bromide; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1021/ol102177j

upstream raw materials:

methyl (3S,7R)-9-(tert-butyldiphenylsilyloxy)-3,7-dimethyl-6-(triethylsilyloxy)nonanoate

Downstream raw materials:

(7R)-10,10-diethyl-2,2,7-trimethyl-8-((S)-3-methylhex-5-enyl)-3,3-diphenyl-4,9-dioxa-3,10-disiladodecane