(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionic acid

Base Information

Chemical Name:(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionic acid
CAS No.:208938-35-6
Molecular Formula:C₁₆H₂₆O₃Si
Molecular Weight:294.466
Hs Code.:

Synonyms:(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionic acid

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Chemical Property of (S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionic acid

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Technology Process of (S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionic acid

There total 4 articles about (S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 208938-33-4
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionaldehyde

: 208938-35-6
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionic acid

Guidance literature:: With sodium periodate; ruthenium tetroxide; In tetrachloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(98)00576-0

Reference yield:

: tert-Butyl-dimethyl-((E)-3-phenyl-but-2-enyloxy)-silane

: 208938-35-6
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / AD-mix-α, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 0 °C

2: 1.) MsCl, Et₃N, 2.) K₂CO₃ / 1.) CH₂Cl₂, -78 deg C, 2.) MeOH

3: 97 percent / methylaluminium bis(4-bromo-2,6-di-tert-butyl-phenoxide (MABR) / CH₂Cl₂ / -78 °C

4: 87 percent / RuO₄, NaIO₄ / CCl₄; acetonitrile; H₂O

With sodium periodate; AD-mix-α; ruthenium tetroxide; methanesulfonamide; potassium carbonate; methanesulfonyl chloride; methylaluminium bis(4-bromo-2,6-di-tert.-butylphenoxide); triethylamine; In tetrachloromethane; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1016/S0040-4039(98)00576-0

Reference yield:

: 208938-26-5
(2S,3S)-1-(tert-Butyl-dimethyl-silanyloxy)-3-phenyl-butane-2,3-diol

: 208938-35-6
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) MsCl, Et₃N, 2.) K₂CO₃ / 1.) CH₂Cl₂, -78 deg C, 2.) MeOH

2: 97 percent / methylaluminium bis(4-bromo-2,6-di-tert-butyl-phenoxide (MABR) / CH₂Cl₂ / -78 °C

3: 87 percent / RuO₄, NaIO₄ / CCl₄; acetonitrile; H₂O

With sodium periodate; ruthenium tetroxide; potassium carbonate; methanesulfonyl chloride; methylaluminium bis(4-bromo-2,6-di-tert.-butylphenoxide); triethylamine; In tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(98)00576-0