2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl phosphite

Base Information

• Chemical Name: 2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl phosphite
• CAS No.: 214152-30-4
• Molecular Formula: C₅₀H₆₂N₅O₁₃PSi
• Molecular Weight: 1000.13

Synonyms:2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl phosphite

Chemical Property of 2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl phosphite

Chemical Property:

Purity/Quality:

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Technology Process of 2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl phosphite

There total 13 articles about 2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl phosphite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] (98796-51-1) + 3'-O-(t-butyldimethylsilyl)thymidine (40733-27-5) → 2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl phosphite (214152-30-4)

Guidance literature:

With 5-(ethylthio)-1H-tetrazole; for 0.5h; Milling;

DOI:10.1002/chem.202001193

Reference yield: 65.0%

2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(tertbutyldimethylsilyl)thymidin-5'-yl boranophosphate → 2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl phosphite (214152-30-4,1308795-28-9,1308795-29-0)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In dichloromethane; at 20 ℃; for 37h;

DOI:10.1016/j.ica.2010.11.022

Reference yield: 60.0%

2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(tertbutyldimethylsilyl)thymidin-5'-yl boranophosphate → 2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl phosphite (214152-30-4,1308795-28-9,1308795-29-0)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In dichloromethane; at 20 ℃; for 37h;

DOI:10.1016/j.ica.2010.11.022

upstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]

3'-O-(t-butyldimethylsilyl)thymidine

2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl phosphite

Downstream raw materials:

2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl phosphite

2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl phosphite

C₅₀H₆₂N₅O₁₃PSSi

C₅₀H₆₂N₅O₁₃PSSi

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