Technology Process of C31H44N8O5
There total 10 articles about C31H44N8O5 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C19H25N5O4;
With
N-ethyl-N,N-diisopropylamine; HATU;
In
dichloromethane;
at 0 ℃;
for 0.0833333h;
C12H21N3O2*ClH;
In
dichloromethane;
at 0 ℃;
DOI:10.1021/ol303572t
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium hydroxide / water; methanol / 0 - 20 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.08 h / 0 °C
2.2: 0 °C
3.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 0 °C
4.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 0 °C
4.2: 0 °C
With
4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol303572t
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium azide / acetone; water / Reflux
2.1: potassium hydroxide / water; methanol / 0 - 20 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.08 h / 0 °C
3.2: 0 °C
4.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 0 °C
5.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 0 °C
5.2: 0 °C
With
4-methyl-morpholine; sodium azide; 1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol303572t