methyl 1-((5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)methyl)azetidine-3-carboxylate

Base Information

Chemical Name:methyl 1-((5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)methyl)azetidine-3-carboxylate
CAS No.:1220971-99-2
Molecular Formula:C₂₆H₂₇N₃O₆
Molecular Weight:477.517
Hs Code.:

Synonyms:methyl 1-((5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)methyl)azetidine-3-carboxylate

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Chemical Property of methyl 1-((5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)methyl)azetidine-3-carboxylate

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Technology Process of methyl 1-((5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)methyl)azetidine-3-carboxylate

There total 8 articles about methyl 1-((5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)methyl)azetidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 100202-39-9
methyl 3-azetidinecarboxylate hydrochloride

: 1220971-97-0
5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-carbaldehyde

: 1220971-99-2
methyl 1-((5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)methyl)azetidine-3-carboxylate

Guidance literature:: methyl 3-azetidinecarboxylate hydrochloride; 5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-carbaldehyde; With N-ethyl-N,N-diisopropylamine; In methanol; 1,2-dichloro-ethane; at 20 ℃; for 0.5h; Sonication;

With sodium triacetoxy borohydride; acetic acid; In methanol; 1,2-dichloro-ethane; at 20 ℃; for 1h;

Reference yield: 68.0%

: 100202-39-9
methyl 3-azetidinecarboxylate hydrochloride

: 1220971-94-7
5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-carboxylic acid

: 1220971-99-2
methyl 1-((5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)methyl)azetidine-3-carboxylate

Guidance literature:: methyl 3-azetidinecarboxylate hydrochloride; 5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; In methanol; 1,2-dichloro-ethane; at 20 ℃; for 0.5h; Sonication;

With sodium tris(acetoxy)borohydride; acetic acid; In methanol; 1,2-dichloro-ethane; at 20 ℃; for 1h;

Reference yield:

: 1220971-95-8
N-hydroxy-2-(hydroxymethyl)benzofuran-5-carboximidamide

: 1220971-99-2
methyl 1-((5-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)methyl)azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide / 0.33 h / 40 °C / Inert atmosphere

1.2: 20 - 120 °C / Inert atmosphere

2.1: manganese(IV) oxide / 1,4-dioxane / 1 h / Reflux

3.1: silver nitrate; potassium hydroxide / water; ethanol / 1 h / 50 °C

4.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane; methanol / 0.5 h / 20 °C / Sonication

4.2: 1 h / 20 °C

With manganese(IV) oxide; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; 1,2-dichloro-ethane;