3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE

Base Information

• Chemical Name: 3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE
• CAS No.: 100202-39-9
• Molecular Formula: C5H9NO2^.HCl
• Molecular Weight: 151.593
• Hs Code.: 2933990090
• Mol file: 100202-39-9.mol

Synonyms:3-Azetidinecarboxylicacid, methyl ester, hydrochloride (9CI);Azetidine-3-carboxylic acid methyl ester hydrochloride;

Chemical Property of 3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE

Chemical Property:

• Melting Point: 93.0 to 97.0 °C
• Boiling Point: 190.9 °C at 760 mmHg
• Flash Point: 69.3 °C
• PSA: 38.33000
• LogP: 0.50960
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Soluble in water

Purity/Quality:

98%, ^*data from raw suppliers

Methyl Azetidine-3-carboxylate Hydrochloride ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl Azetidine-3-carboxylate Hydrochloride can be used to prepare inhibitors of of human glycogen phosphorylase to treat hyperglycemia, hyperinsulinemia, hyperlipidemia, insulin resistance or tissue ischemia.

Technology Process of 3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE

There total 4 articles about 3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(diphenylmethyl)-3-methoxycarbonylazetidine (53871-06-0) → methyl 3-azetidinecarboxylate hydrochloride (100202-39-9)

Guidance literature:

With hydrogenchloride; hydrogen; palladium(II) hydroxide/carbon; In methanol; ethyl acetate; at 20 ℃; for 11h; under 3000.3 Torr;

Reference yield: 100.0%

methanol (67-56-1) + 3-azetidinecarboxylic acid (36476-78-5) → methyl 3-azetidinecarboxylate hydrochloride (100202-39-9)

Guidance literature:

With thionyl chloride; In acetonitrile; at 0 - 20 ℃; for 2.33333h;

Reference yield: 100.0%

3-azetidinecarboxylic acid (36476-78-5) → methyl 3-azetidinecarboxylate hydrochloride (100202-39-9)

Guidance literature:

With chloro-trimethyl-silane; In methanol;

upstream raw materials:

1-(diphenylmethyl)-3-methoxycarbonylazetidine

methanol

3-azetidinecarboxylic acid

Downstream raw materials:

azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester

1-[1-(4-chloro-phenyl)-cyclobutanecarbonyl]-azetidine-3-carboxylic acid methyl ester

C₁₉H₁₆BrFN₂O₂S

2317157

Refernces

• 1、 -. "Carbonyl azetidine substituted naphthalimide fluorescent dye as well as synthesis method and application thereof". Paragraph 0097-0101. . Retrieved 2021/06/13.
• 2、 -. "Carbonyl azetidine substituted NBD fluorescent dye as well as synthesis method and application thereof". Paragraph 0059-0063. . Retrieved 2021/06/12.