4-nitro tartranilic acid salt of (R)-isomer of 4-benzyl salbutamol

Base Information

• Chemical Name: 4-nitro tartranilic acid salt of (R)-isomer of 4-benzyl salbutamol
• CAS No.: 1005420-21-2
• Molecular Formula: C₁₀H₁₀N₂O₇*C₂₀H₂₇NO₃
• Molecular Weight: 599.638
• Mol file: 1005420-21-2.mol

Synonyms:4-nitro tartranilic acid salt of (R)-isomer of 4-benzyl salbutamol

Chemical Property of 4-nitro tartranilic acid salt of (R)-isomer of 4-benzyl salbutamol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-nitro tartranilic acid salt of (R)-isomer of 4-benzyl salbutamol

There total 1 articles about 4-nitro tartranilic acid salt of (R)-isomer of 4-benzyl salbutamol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

α1-[[(1,1-dimethylethyl)amino]methyl]-4-(benzyloxy)-1,3-benzenedimethanol (56796-66-8) + Lg-tartaric acid mono-(4-nitro-anilide) (60908-35-2,206761-80-0) → 4-nitro tartranilic acid salt of (R)-isomer of 4-benzyl salbutamol (1005420-21-2)

Guidance literature:

α¹-[[(1,1-dimethylethyl)amino]methyl]-4-(benzyloxy)-1,3-benzenedimethanol; L_g-tartaric acid mono-(4-nitro-anilide); In ethyl acetate; isopropyl alcohol; at 75 ℃; for 44h; Resolution of racemate;

In ethyl acetate; isopropyl alcohol; at 70 - 75 ℃; for 2h;

Reference yield: 90.0%

4-nitro tartranilic acid salt of (R)-isomer of 4-benzyl salbutamol (1005420-21-2) → (R)-1-[4-benzyloxy-3-hydroxymethylphenyl]-2-tert-butylaminoethanol (174607-68-2)

Guidance literature:

4-nitro tartranilic acid salt of (R)-isomer of 4-benzyl salbutamol; With formic acid; In water; for 1h;

With ammonia; In water; at 8 - 10 ℃; pH=9.5 - 10;

Reference yield:

formic acid (64-18-6) + 4-nitro tartranilic acid salt of (R)-isomer of 4-benzyl salbutamol (1005420-21-2) → (R)-4-benzyl salbutamol formate (1005420-22-3)

Guidance literature:

In water; for 1h;

upstream raw materials:

α¹-[[(1,1-dimethylethyl)amino]methyl]-4-(benzyloxy)-1,3-benzenedimethanol

L_g-tartaric acid mono-(4-nitro-anilide)

Downstream raw materials:

(R)-1-[4-benzyloxy-3-hydroxymethylphenyl]-2-tert-butylaminoethanol

(R)-4-benzyl salbutamol formate

Refernces

• 1、 -. "A PROCESS FOR THE PREPARATION OF OPTICALLY PURE R (-) SALBUTAMOL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS". Page/Page column 9-10. . Retrieved 2008/06/13.