ethyl 7-(1-tert-butoxycarbonylcyclopropyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

Base Information

Chemical Name:ethyl 7-(1-tert-butoxycarbonylcyclopropyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate
CAS No.:123821-78-3
Molecular Formula:C₂₅H₂₃F₃N₂O₅
Molecular Weight:488.463
Hs Code.:

Synonyms:ethyl 7-(1-tert-butoxycarbonylcyclopropyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

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Chemical Property of ethyl 7-(1-tert-butoxycarbonylcyclopropyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

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Technology Process of ethyl 7-(1-tert-butoxycarbonylcyclopropyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

There total 4 articles about ethyl 7-(1-tert-butoxycarbonylcyclopropyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 106-93-4
ethylene dibromide

: 123822-19-5
7-tert-Butoxycarbonylmethyl-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester

: 123821-78-3
ethyl 7-(1-tert-butoxycarbonylcyclopropyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 45 - 55 ℃; for 18h;
DOI:10.1248/cpb.42.2063

Reference yield:

: 1694-31-1
tert-butyl acetoacetate

: 123821-78-3
ethyl 7-(1-tert-butoxycarbonylcyclopropyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / NaH / dimethylformamide / 20 h / Ambient temperature

2: 64 percent / hydrazine hydrate / ethanol / 6 h / Ambient temperature

3: 27 percent / NaH / dimethylformamide / 18 h / 45 - 55 °C

With sodium hydride; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.2063

Reference yield:

: 100491-29-0
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

: 123821-78-3
ethyl 7-(1-tert-butoxycarbonylcyclopropyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / NaH / dimethylformamide / 20 h / Ambient temperature

2: 64 percent / hydrazine hydrate / ethanol / 6 h / Ambient temperature

3: 27 percent / NaH / dimethylformamide / 18 h / 45 - 55 °C

With sodium hydride; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.2063