(1R,5S,6S)-6-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-5-methyl-2-[(S)-2-methyl-3-oxo-prop-(Z)-ylidene]-cyclohex-3-enecarboxylic acid methyl ester

Base Information

Chemical Name:(1R,5S,6S)-6-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-5-methyl-2-[(S)-2-methyl-3-oxo-prop-(Z)-ylidene]-cyclohex-3-enecarboxylic acid methyl ester
CAS No.:1026249-35-3
Molecular Formula:C₃₉H₅₄O₆Si
Molecular Weight:646.94
Hs Code.:

(1R,5S,6S)-6-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-5-methyl-2-[(S)-2-methyl-3-oxo-prop-(Z)-ylidene]-cyclohex-3-enecarboxylic acid methyl ester

Synonyms:(1R,5S,6S)-6-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-5-methyl-2-[(S)-2-methyl-3-oxo-prop-(Z)-ylidene]-cyclohex-3-enecarboxylic acid methyl ester

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Chemical Property of (1R,5S,6S)-6-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-5-methyl-2-[(S)-2-methyl-3-oxo-prop-(Z)-ylidene]-cyclohex-3-enecarboxylic acid methyl ester

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Technology Process of (1R,5S,6S)-6-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-5-methyl-2-[(S)-2-methyl-3-oxo-prop-(Z)-ylidene]-cyclohex-3-enecarboxylic acid methyl ester

There total 7 articles about (1R,5S,6S)-6-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-5-methyl-2-[(S)-2-methyl-3-oxo-prop-(Z)-ylidene]-cyclohex-3-enecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 67-56-1
methanol

: 161466-52-0
(2S,3S,7S,8S,8aR)-8-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-2-hydroxy-3,7-dimethyl-3,7,8,8a-tetrahydro-2H-naphthalen-1-one

: 1026249-35-3
(1R,5S,6S)-6-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-5-methyl-2-[(S)-2-methyl-3-oxo-prop-(Z)-ylidene]-cyclohex-3-enecarboxylic acid methyl ester

Guidance literature:: With lead(IV) acetate; In benzene;
DOI:10.1021/jo00110a051

Reference yield:

: 116996-45-3
<1S-<1α,3α,7β,8β(4S^*,6R^*),8aβ>>-8-<2-<6-<2-<<(1,1-dimethylethyl)diphenylsilyl>oxy>ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl>-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-1-naphthalenol

: 1026249-35-3
(1R,5S,6S)-6-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-5-methyl-2-[(S)-2-methyl-3-oxo-prop-(Z)-ylidene]-cyclohex-3-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / Swern oxidation

2: 99 percent / LDA, BuLi / tetrahydrofuran

3: 70 percent / m-CPBA, NaHCO₃ / ethyl acetate

4: 81 percent / Pb(OAc)4 / benzene

With lead(IV) acetate; n-butyllithium; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/jo00110a051

Reference yield:

: 75330-75-5,79952-44-6
lovastatin

: 1026249-35-3
(1R,5S,6S)-6-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-5-methyl-2-[(S)-2-methyl-3-oxo-prop-(Z)-ylidene]-cyclohex-3-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / LiAlH₄ / tetrahydrofuran / 5 h

2: 100 percent / imidazole / dimethylformamide / Ambient temperature

3: 82 percent / p-TsOH*H₂O

4: 87 percent / Swern oxidation

5: 99 percent / LDA, BuLi / tetrahydrofuran

6: 70 percent / m-CPBA, NaHCO₃ / ethyl acetate

7: 81 percent / Pb(OAc)4 / benzene

With 1H-imidazole; lead(IV) acetate; lithium aluminium tetrahydride; n-butyllithium; sodium hydrogencarbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00110a051