(S)-methyl 2-[2-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyloxy)-3,3-dimethylbutyl]oxazole-4-carboxylate

Base Information

Chemical Name:(S)-methyl 2-[2-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyloxy)-3,3-dimethylbutyl]oxazole-4-carboxylate
CAS No.:1466431-01-5
Molecular Formula:C₂₅H₃₉NO₆Si
Molecular Weight:477.673
Hs Code.:

Synonyms:(S)-methyl 2-[2-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyloxy)-3,3-dimethylbutyl]oxazole-4-carboxylate

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Chemical Property of (S)-methyl 2-[2-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyloxy)-3,3-dimethylbutyl]oxazole-4-carboxylate

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Technology Process of (S)-methyl 2-[2-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyloxy)-3,3-dimethylbutyl]oxazole-4-carboxylate

There total 7 articles about (S)-methyl 2-[2-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyloxy)-3,3-dimethylbutyl]oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1466431-00-4
C₂₅H₄₁NO₆Si

: 1466431-01-5
(S)-methyl 2-[2-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyloxy)-3,3-dimethylbutyl]oxazole-4-carboxylate

Guidance literature:: With Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1055/s-0033-1338493

Reference yield:

: 1414941-22-2
(S)-tert-butyl(1-(4-methoxybenzyloxy)-2,2-dimethylhex-5-en-3-yloxy)dimethylsilane

: 1466431-01-5
(S)-methyl 2-[2-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyloxy)-3,3-dimethylbutyl]oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: ozone; triphenylphosphine / dichloromethane / -78 - 20 °C

2: sodium chlorite; 2-methyl-but-2-ene; sodium dihydrogenphosphate / tert-butyl alcohol; water / 1.5 h / 20 °C / Inert atmosphere

3: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -30 - 20 °C / Inert atmosphere

4: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C / Inert atmosphere

5: 1,8-diazabicyclo[5.4.0]undec-7-ene; Bromotrichloromethane / dichloromethane / -78 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; Bromotrichloromethane; diethylamino-sulfur trifluoride; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1055/s-0033-1338493

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 1466431-01-5
(S)-methyl 2-[2-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyloxy)-3,3-dimethylbutyl]oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: ozone; triphenylphosphine / dichloromethane / -78 - 20 °C

3: sodium chlorite; 2-methyl-but-2-ene; sodium dihydrogenphosphate / tert-butyl alcohol; water / 1.5 h / 20 °C / Inert atmosphere

4: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -30 - 20 °C / Inert atmosphere

5: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C / Inert atmosphere

6: 1,8-diazabicyclo[5.4.0]undec-7-ene; Bromotrichloromethane / dichloromethane / -78 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; 2,6-dimethylpyridine; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; Bromotrichloromethane; diethylamino-sulfur trifluoride; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1055/s-0033-1338493