1-methyl-N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)piperidine-4-carboxamide

Base Information

Chemical Name:1-methyl-N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)piperidine-4-carboxamide
CAS No.:1372590-73-2
Molecular Formula:C₂₈H₃₁N₅O₄S
Molecular Weight:533.651
Hs Code.:

Synonyms:1-methyl-N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)piperidine-4-carboxamide

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Chemical Property of 1-methyl-N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)piperidine-4-carboxamide

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Technology Process of 1-methyl-N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)piperidine-4-carboxamide

There total 11 articles about 1-methyl-N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68947-43-3
1-methylpiperidine-4-carboxylic acid

: 1372590-71-0
N-[2-(7-amino-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-3-yl)phenyl]-N-methylmethanesulfonamide

: 1372590-73-2
1-methyl-N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)piperidine-4-carboxamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 18h;

Reference yield:

: 2-amino-4-(N-tert-butoxycarbonylamino)nitrobenzene

: 1372590-73-2
1-methyl-N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 16 h / 95 °C

2.1: hydrogen / Raney Ni / tetrahydrofuran; methanol / 3 h / 20 °C / 1551.49 Torr

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 60 °C

3.2: 20 °C / pH 6

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 96 h / 20 °C

5.1: caesium carbonate / dihydrogen dichloro-bis(di-tert-butylphosphinito-κP)palladium(2-) / N,N-dimethyl-formamide; water / 0.5 h / 150 °C / Microwave irradiation

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 18 h / 25 °C

With water; hydrogen; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; dihydrogen dichloro-bis(di-tert-butylphosphinito-κP)palladium(2-); palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1.1: Buchwald-Hartwig amination / 5.1: Suzuki Coupling;

Reference yield:

: 181765-85-5
methyl 2-iodo 4-chlorobenzoate

: 1372590-73-2
1-methyl-N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-7-yl)piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 16 h / 95 °C

2.1: hydrogen / Raney Ni / tetrahydrofuran; methanol / 3 h / 20 °C / 1551.49 Torr

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 60 °C

3.2: 20 °C / pH 6

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 96 h / 20 °C

5.1: caesium carbonate / dihydrogen dichloro-bis(di-tert-butylphosphinito-κP)palladium(2-) / N,N-dimethyl-formamide; water / 0.5 h / 150 °C / Microwave irradiation

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 18 h / 25 °C

With water; hydrogen; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; dihydrogen dichloro-bis(di-tert-butylphosphinito-κP)palladium(2-); palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1.1: Buchwald-Hartwig amination / 5.1: Suzuki Coupling;