(S)-2-[3-((R)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-pyrazol-1-yl]-3-methyl-butyric acid methyl ester

Base Information

Chemical Name:(S)-2-[3-((R)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-pyrazol-1-yl]-3-methyl-butyric acid methyl ester
CAS No.:258833-80-6
Molecular Formula:C₁₉H₂₅N₃O₅
Molecular Weight:375.425
Hs Code.:

Synonyms:(S)-2-[3-((R)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-pyrazol-1-yl]-3-methyl-butyric acid methyl ester

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Chemical Property of (S)-2-[3-((R)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-pyrazol-1-yl]-3-methyl-butyric acid methyl ester

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Technology Process of (S)-2-[3-((R)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-pyrazol-1-yl]-3-methyl-butyric acid methyl ester

There total 8 articles about (S)-2-[3-((R)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-pyrazol-1-yl]-3-methyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 67-56-1
methanol

: 258830-58-9
(R)-4-[1-((S)-1-Carboxy-2-methyl-propyl)-1H-pyrazol-3-yl]-oxazolidine-3-carboxylic acid benzyl ester

: 258833-80-6
(S)-2-[3-((R)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-pyrazol-1-yl]-3-methyl-butyric acid methyl ester

Guidance literature:: With toluene-4-sulfonic acid; for 24h; Heating;
DOI:10.1016/S0040-4039(99)01847-X

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 258833-80-6
(S)-2-[3-((R)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-pyrazol-1-yl]-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4 h / 60 °C

2.1: NaOCl; KOH / 2 h / 90 °C

2.2: toluene; aq. HCl / 0.5 h / 80 °C

2.3: 64 percent / Et₂NH / ethanol

3.1: 75 percent / Na₂CO₃ / methanol / 12 h / 65 °C

4.1: 90 percent / PTSA / 24 h / Heating

With potassium hydroxide; sodium hypochlorite; sodium carbonate; toluene-4-sulfonic acid; In methanol; 1.1: Addition / 2.1: Oxidation / 2.2: hydrazonolysis / 2.3: Hydrolysis / 3.1: Cyclization / 4.1: Esterification;
DOI:10.1016/S0040-4039(99)01847-X

Reference yield:

: 97534-82-2,97534-84-4
(4S)-3-[(benzyloxy)carbonyl]-1,3-oxazolidine-4-carboxylic acid

: 258833-80-6
(S)-2-[3-((R)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-pyrazol-1-yl]-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: MMM / CH₂Cl₂ / -20 °C

2: 25 °C

3: 80 percent / diethyl ether / 25 °C

4: 75 percent / Na₂CO₃ / methanol / 12 h / 65 °C

5: 90 percent / PTSA / 24 h / Heating

With monomethyl maleate; sodium carbonate; toluene-4-sulfonic acid; In methanol; diethyl ether; dichloromethane; 1: Acylation / 2: Acylation / 3: Alkylation / 4: Cyclization / 5: Esterification;
DOI:10.1016/S0040-4039(99)01847-X