4-[[2-(2-Amino-4-hydroxy-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-benzoic acid

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Chemical Name:4-[[2-(2-Amino-4-hydroxy-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-benzoic acid
CAS No.:111113-71-4
Molecular Formula:C₁₈H₁₄F₃N₅O₄
Molecular Weight:421.335
Hs Code.:

Synonyms:4-[[2-(2-Amino-4-hydroxy-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-benzoic acid

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Chemical Property of 4-[[2-(2-Amino-4-hydroxy-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-benzoic acid

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Technology Process of 4-[[2-(2-Amino-4-hydroxy-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-benzoic acid

There total 7 articles about 4-[[2-(2-Amino-4-hydroxy-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 111113-70-3
8-deazahomopteroic acid

: 407-25-0
trifluoroacetic anhydride

: 111113-71-4
4-[[2-(2-Amino-4-hydroxy-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-benzoic acid

Guidance literature:: for 3h; Heating;
DOI:10.1021/jm00396a022

Reference yield:

: 111113-65-6
4-{Acetyl-[3-oxo-4-(triphenyl-λ⁵-phosphanylidene)-butyl]-amino}-benzoic acid ethyl ester

: 111113-71-4
4-[[2-(2-Amino-4-hydroxy-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) bis(trifluoromethylsilyl)trifluoroacetamide / 1.) DMF, 1 h, 2.) 65 h

2: 48 percent / H₂ / Rh/C / dimethylformamide / 125 h

3: 1.) HCl, EtOH, 2.) Na₂CO₃, NaOH / 1.) reflux, 45 min, 2.) C₆H₆, pH 8, 0 deg C, 30 min

4: 78 percent / H₂ / Pd black / dimethylformamide / 30 h / 760 Torr

5: 46 percent / aq. NaOH / 2.5 h / 90 °C

6: 100 percent / 3 h / Heating

With hydrogenchloride; sodium hydroxide; ethanol; bis(trifluoromethylsilyl)trifluoroacetamide; hydrogen; sodium carbonate; Rh on carbon; palladium; In N,N-dimethyl-formamide;
DOI:10.1021/jm00396a022

Reference yield:

: 111113-67-8
1-(2'-acetamido-4'-hydroxy-6'-pyrimidinyl)-5-(N-acetyl-p-carbethoxyanilino)pentan-3-one

: 111113-71-4
4-[[2-(2-Amino-4-hydroxy-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) HCl, EtOH, 2.) Na₂CO₃, NaOH / 1.) reflux, 45 min, 2.) C₆H₆, pH 8, 0 deg C, 30 min

2: 78 percent / H₂ / Pd black / dimethylformamide / 30 h / 760 Torr

3: 46 percent / aq. NaOH / 2.5 h / 90 °C

4: 100 percent / 3 h / Heating

With hydrogenchloride; sodium hydroxide; ethanol; hydrogen; sodium carbonate; palladium; In N,N-dimethyl-formamide;
DOI:10.1021/jm00396a022