N-(4-t-butylbenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine

Base Information

• Chemical Name: N-(4-t-butylbenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine
• CAS No.: 1322645-07-7
• Molecular Formula: C₃₀H₄₇N₃O₄S₂
• Molecular Weight: 577.853
• Mol file: 1322645-07-7.mol

Synonyms:N-(4-t-butylbenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine

Chemical Property of N-(4-t-butylbenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-t-butylbenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine

There total 7 articles about N-(4-t-butylbenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

4-tert-butylbenzenesulfonyl chloride (15084-51-2) + N-(3-((3-aminopropyl)(cyclohexylmethyl)amino)propyl)-4-methylbenzenesulfonamide (1322645-03-3) → N-(4-t-butylbenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine (1322645-07-7)

Guidance literature:

With sodium carbonate; In dichloromethane; water; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jm2002603

Reference yield:

C17H26N2O2S → N-(4-t-butylbenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine (1322645-07-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / ethanol / 12 h / 20 °C / Inert atmosphere

2.1: sodium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux

3.1: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

3.2: 1.5 h / Inert atmosphere

4.1: sodium carbonate / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium carbonate; hydrazine hydrate; In ethanol; dichloromethane; water; acetonitrile;

DOI:10.1021/jm2002603

Reference yield:

N-(p-toluenesulfonamidopropyl)cyclohexylmethylamine (1322644-99-4) → N-(4-t-butylbenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine (1322645-07-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux

2.1: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

2.2: 1.5 h / Inert atmosphere

3.1: sodium carbonate / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

With sodium carbonate; hydrazine hydrate; In ethanol; dichloromethane; water; acetonitrile;

DOI:10.1021/jm2002603

upstream raw materials:

4-tert-butylbenzenesulfonyl chloride

N-(3-((3-aminopropyl)(cyclohexylmethyl)amino)propyl)-4-methylbenzenesulfonamide

N-(p-toluenesulfonamidopropyl)cyclohexylmethylamine

N-phthaloyl-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine

Downstream raw materials:

9-cyclohexylmethyl-1-(4-t-butylbenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane

N-(4-t-butylbenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride

9-cyclohexylmethyl-1-(4-t-butylbenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride