tert-butyl 2-(4-chloro-3-(2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-phenylethylcarbamate

Base Information

Chemical Name:tert-butyl 2-(4-chloro-3-(2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-phenylethylcarbamate
CAS No.:1386981-07-2
Molecular Formula:C₂₉H₂₉ClN₆O₅
Molecular Weight:577.039
Hs Code.:

Synonyms:tert-butyl 2-(4-chloro-3-(2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-phenylethylcarbamate

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Chemical Property of tert-butyl 2-(4-chloro-3-(2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-phenylethylcarbamate

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Technology Process of tert-butyl 2-(4-chloro-3-(2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-phenylethylcarbamate

There total 9 articles about tert-butyl 2-(4-chloro-3-(2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.2%

: 1386981-05-0
4-chloro-3-(2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzoic acid

: 174885-99-5
(±)-tert-butyl N-(2-amino-2-phenylethyl)carbamate

: 1386981-07-2
tert-butyl 2-(4-chloro-3-(2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-phenylethylcarbamate

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 6h; Inert atmosphere;

Reference yield:

: 698-29-3
2-methyl-4-amino-5-cyanopyrimidine

: 1386981-07-2
tert-butyl 2-(4-chloro-3-(2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen; sulfuric acid / palladium 10% on activated carbon / water / 1.25 h / 20 °C / 1551.49 - 2585.81 Torr

2: potassium carbonate; triethylamine / N,N-dimethyl-formamide / 85 °C / Inert atmosphere

3: water; lithium hydroxide / methanol / 4 h / 65 °C

4: triethylamine; HATU / N,N-dimethyl-formamide / 5 h

5: water; lithium hydroxide / methanol / 60 - 65 °C

6: triethylamine; HATU / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

With sulfuric acid; water; hydrogen; potassium carbonate; triethylamine; HATU; lithium hydroxide; palladium 10% on activated carbon; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1386981-07-2
tert-butyl 2-(4-chloro-3-(2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0.5 h / 0 - 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C

3: hydrazine hydrate / tetrahydrofuran; methanol / 15 h / 65 °C

4: triethylamine; HATU / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

With hydrazine hydrate; triethylamine; triphenylphosphine; HATU; diethylazodicarboxylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;