5-Fluoro-2,3-dihydro-1,4-benzodioxine

Base Information

Chemical Name:5-Fluoro-2,3-dihydro-1,4-benzodioxine
CAS No.:69464-49-9
Molecular Formula:C₈H₇FO₂
Molecular Weight:154.141
Hs Code.:2932990090
European Community (EC) Number:867-556-1

Synonyms:5-Fluoro-2,3-dihydro-1,4-benzodioxine;69464-49-9;5-fluoro-2,3-dihydrobenzo[b][1,4]dioxine;SCHEMBL2306687;DRSLFPHWBGATPA-UHFFFAOYSA-N;MFCD27927511;5-fluoro-2,3-dihydro-1,4-benzodioxin;SY308747;CS-0146235;E74172;EN300-6759748

Suppliers and Price of 5-Fluoro-2,3-dihydro-1,4-benzodioxine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Apolloscientific
5-Fluoro-2,3-dihydro-1,4-benzodioxine
5g
$ 555.00

Apolloscientific
5-Fluoro-2,3-dihydro-1,4-benzodioxine
1g
$ 185.00

Apolloscientific
5-Fluoro-2,3-dihydro-1,4-benzodioxine
250mg
$ 60.00

Total 4 raw suppliers

Chemical Property of 5-Fluoro-2,3-dihydro-1,4-benzodioxine

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:154.04300762
Heavy Atom Count:11
Complexity:140

Purity/Quality:

98%+ ^*data from raw suppliers

5-Fluoro-2,3-dihydro-1,4-benzodioxine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COC2=C(O1)C=CC=C2F

Technology Process of 5-Fluoro-2,3-dihydro-1,4-benzodioxine

There total 2 articles about 5-Fluoro-2,3-dihydro-1,4-benzodioxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.8%

: 363-52-0
3-fluorocatechol

: 106-93-4
ethylene dibromide

: 69464-49-9
5-fluoro-2,3-dihydrobenzo[b][1,4]dioxine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 24h;

Reference yield: 92.0%

: 363-52-0
3-fluorocatechol

: 107-04-0
1-Bromo-2-chloroethane

: 69464-49-9
5-fluoro-2,3-dihydrobenzo[b][1,4]dioxine

Guidance literature:: 3-fluorocatechol; With potassium carbonate; In N,N-dimethyl-formamide; at 23 ℃; for 0.166667h;

1-Bromo-2-chloroethane; In N,N-dimethyl-formamide; at 23 - 95 ℃; for 17h;

Reference yield:

: 69464-49-9
5-fluoro-2,3-dihydrobenzo[b][1,4]dioxine

: N-(3-bromo-2-fluorophenyl)-10-fluoro-7,8-dihydro[1,4]dioxino[2,3-g]quinazolin-4-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / methanol / 0.5 h / 70 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 °C

3.1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 10 - 85 °C

3.2: 1.5 h / 23 °C

4.1: trifluoroacetic acid; hexamethylenetetramine / 0.17 h / 110 °C / Microwave irradiation

4.2: 0.67 h / 100 °C / Microwave irradiation

5.1: acetic acid; ammonium cerium (IV) nitrate / water / 15 h / 23 °C

6.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / 6 h / 10 - 90 °C

7.1: hydrogenchloride / acetonitrile; 1,4-dioxane / 0.5 h / 80 °C / Microwave irradiation

With hydrogenchloride; N-Bromosuccinimide; n-butyllithium; ammonium cerium (IV) nitrate; hexamethylenetetramine; diphenyl phosphoryl azide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; toluene; acetonitrile;