methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino}ethyl)-3-(cyclohexyloxy)-4-biphenylcarboxylate

Base Information

• Chemical Name: methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino}ethyl)-3-(cyclohexyloxy)-4-biphenylcarboxylate
• CAS No.: 881408-77-1
• Molecular Formula: C₃₄H₄₂N₂O₆
• Molecular Weight: 574.717

Synonyms:methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino}ethyl)-3-(cyclohexyloxy)-4-biphenylcarboxylate

Chemical Property of methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino}ethyl)-3-(cyclohexyloxy)-4-biphenylcarboxylate

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Technology Process of methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino}ethyl)-3-(cyclohexyloxy)-4-biphenylcarboxylate

There total 1 articles about methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino}ethyl)-3-(cyclohexyloxy)-4-biphenylcarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

tert-butyl [2-(4-bromophenyl)ethyl][(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]carbamate (855481-96-8) + [3-(cyclohexyloxy)-4-(methoxycarbonyl)phenyl]boronic acid (855482-72-3) → methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino}ethyl)-3-(cyclohexyloxy)-4-biphenylcarboxylate (881408-77-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 70 ℃; for 5h; Inert atmosphere;

DOI:10.1021/jm8000345

Reference yield:

methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino}ethyl)-3-(cyclohexyloxy)-4-biphenylcarboxylate (881408-77-1) + tert-butyldimethylsilyl chloride (18162-48-6) → methyl 4'-[2-[(tert-butoxycarbonyl)[(2R)-2-[[tert-butyl(dimethyl)silyl]oxy]-2-(3-pyridyl)ethyl]amino]ethyl]-3-(cyclohexyloxy)-4-biphenylcarboxylate (881408-78-2)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 - 35 ℃; for 3.75h;

Reference yield:

methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino}ethyl)-3-(cyclohexyloxy)-4-biphenylcarboxylate (881408-77-1) → C33H40N2O6

Guidance literature:

With methanol; sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jm8000345

upstream raw materials:

tert-butyl [2-(4-bromophenyl)ethyl][(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]carbamate

[3-(cyclohexyloxy)-4-(methoxycarbonyl)phenyl]boronic acid

Downstream raw materials:

methyl 4'-[2-[(tert-butoxycarbonyl)[(2R)-2-[[tert-butyl(dimethyl)silyl]oxy]-2-(3-pyridyl)ethyl]amino]ethyl]-3-(cyclohexyloxy)-4-biphenylcarboxylate

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