(4-(cyclopropanecarbonyl)piperazin-1-yl)(4-((4-methoxyphenyl)thio)phenyl)methanone

Base Information

Chemical Name:(4-(cyclopropanecarbonyl)piperazin-1-yl)(4-((4-methoxyphenyl)thio)phenyl)methanone
CAS No.:1422008-23-8
Molecular Formula:C₂₂H₂₄N₂O₃S
Molecular Weight:396.51
Hs Code.:

Synonyms:(4-(cyclopropanecarbonyl)piperazin-1-yl)(4-((4-methoxyphenyl)thio)phenyl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-(cyclopropanecarbonyl)piperazin-1-yl)(4-((4-methoxyphenyl)thio)phenyl)methanone

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Technology Process of (4-(cyclopropanecarbonyl)piperazin-1-yl)(4-((4-methoxyphenyl)thio)phenyl)methanone

There total 3 articles about (4-(cyclopropanecarbonyl)piperazin-1-yl)(4-((4-methoxyphenyl)thio)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1422008-21-6
S-(4-methoxyphenyl) 4-((4-methoxyphenyl)thio)benzothioate

: 59878-57-8
1-(cyclopropylcarbonyl)piperazine

: 1422008-23-8
(4-(cyclopropanecarbonyl)piperazin-1-yl)(4-((4-methoxyphenyl)thio)phenyl)methanone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 69h;
DOI:10.1021/ol400138m

Reference yield:

: 82102-37-2
9-methyl-9H-fluorene-9-carbonyl chloride

: 1422008-23-8
(4-(cyclopropanecarbonyl)piperazin-1-yl)(4-((4-methoxyphenyl)thio)phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; sodium acetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; N-Methyldicyclohexylamine / 1,2-dimethoxyethane / 18 h / 85 °C

2: potassium carbonate / N,N-dimethyl-formamide / 69 h / 20 °C

With N-Methyldicyclohexylamine; sodium acetate; palladium diacetate; potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/ol400138m

Reference yield:

: 624-38-4,1032416-46-8
para-diiodobenzene

: 1422008-23-8
(4-(cyclopropanecarbonyl)piperazin-1-yl)(4-((4-methoxyphenyl)thio)phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; sodium acetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; N-Methyldicyclohexylamine / 1,2-dimethoxyethane / 18 h / 85 °C

2: potassium carbonate / N,N-dimethyl-formamide / 69 h / 20 °C

With N-Methyldicyclohexylamine; sodium acetate; palladium diacetate; potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/ol400138m