3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester

Base Information

• Chemical Name: 3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester
• CAS No.: 579475-42-6
• Molecular Formula: C₁₉H₁₈N₂O₃
• Molecular Weight: 322.364

Synonyms:3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester

Chemical Property of 3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester

Chemical Property:

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Technology Process of 3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester

There total 1 articles about 3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-nitro-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert.-butyl ester (473547-11-4) + 3-(1-oxy-pyridin-4-yl)-benzoic acid ethyl ester (579475-46-0) + lithium tert.-butyl acetate (66519-62-8) + trimethylsilyl cyanide (7677-24-9) + 3-pyridin-4-yl-benzoic acid ethyl ester (4385-74-4) → 3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (579475-42-6)

Guidance literature:

With dihydrogen peroxide; sodium carbonate; triethylamine; In water; acetonitrile;

Reference yield:

tert-butyl (2-amino-5-methyl-4-(trifluoromethyl)phenyl)carbamate (473537-79-0) + 3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (579475-42-6) → (2-{3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-methyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (579478-80-1)

Guidance literature:

Reference yield:

tert-butyl (2-amino-4-(trifluoromethyl)phenyl)carbamate (579474-48-9) + 3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (579475-42-6) → (2-{3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (579478-79-8)

Guidance literature:

upstream raw materials:

[2-nitro-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert.-butyl ester

3-(1-oxy-pyridin-4-yl)-benzoic acid ethyl ester

lithium tert.-butyl acetate

trimethylsilyl cyanide

Downstream raw materials:

(2-{3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-methyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

(2-{3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

[4-chloro-2-{3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-(2,2,2-trifluoro-ethoxy)-phenyl]-carbamic acid tert-butyl ester

[2-{3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-(2-methoxy-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester

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