2-bromo-N-[(1R)-hydroxymethyl-(2R)-(triisopropylsilanyloxyl)-propyl]-benzamide

Base Information

Chemical Name:2-bromo-N-[(1R)-hydroxymethyl-(2R)-(triisopropylsilanyloxyl)-propyl]-benzamide
CAS No.:716369-28-7
Molecular Formula:C₂₀H₃₄BrNO₃Si
Molecular Weight:444.484
Hs Code.:

Synonyms:2-bromo-N-[(1R)-hydroxymethyl-(2R)-(triisopropylsilanyloxyl)-propyl]-benzamide

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Chemical Property of 2-bromo-N-[(1R)-hydroxymethyl-(2R)-(triisopropylsilanyloxyl)-propyl]-benzamide

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Technology Process of 2-bromo-N-[(1R)-hydroxymethyl-(2R)-(triisopropylsilanyloxyl)-propyl]-benzamide

There total 4 articles about 2-bromo-N-[(1R)-hydroxymethyl-(2R)-(triisopropylsilanyloxyl)-propyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 716369-27-6
(2S)-(2-bromo-benzoylamino)-(3R)-triisopropylsilanyloxybutyric acid methyl ester

: 716369-28-7
2-bromo-N-[(1R)-hydroxymethyl-(2R)-(triisopropylsilanyloxyl)-propyl]-benzamide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 2.5h;
DOI:10.1039/b316502g

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 716369-28-7
2-bromo-N-[(1R)-hydroxymethyl-(2R)-(triisopropylsilanyloxyl)-propyl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / Et₃N / CH₂Cl₂ / 3 h / 0 - 20 °C

2: 71 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 2.5 h / 0 - 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1039/b316502g

Reference yield:

: 7154-66-7
2-bromobenzoic acid chloride

: 716369-28-7
2-bromo-N-[(1R)-hydroxymethyl-(2R)-(triisopropylsilanyloxyl)-propyl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / Et₃N; DMAP / CH₂Cl₂ / 2 h / 0 - 20 °C

2: 62 percent / Et₃N / CH₂Cl₂ / 3 h / 0 - 20 °C

3: 71 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 2.5 h / 0 - 20 °C

With dmap; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1039/b316502g