methyl (S)-3-(1H-indol-3-yl)-2-{(S)-3-isopropyl-4-[(2-nitrophenyl)sulfonyl]-2-oxopiperazin-1-yl}propanoate

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Chemical Name:methyl (S)-3-(1H-indol-3-yl)-2-{(S)-3-isopropyl-4-[(2-nitrophenyl)sulfonyl]-2-oxopiperazin-1-yl}propanoate
CAS No.:1613043-99-4
Molecular Formula:C₂₅H₂₈N₄O₇S
Molecular Weight:528.586
Hs Code.:

Synonyms:methyl (S)-3-(1H-indol-3-yl)-2-{(S)-3-isopropyl-4-[(2-nitrophenyl)sulfonyl]-2-oxopiperazin-1-yl}propanoate

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Chemical Property of methyl (S)-3-(1H-indol-3-yl)-2-{(S)-3-isopropyl-4-[(2-nitrophenyl)sulfonyl]-2-oxopiperazin-1-yl}propanoate

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Technology Process of methyl (S)-3-(1H-indol-3-yl)-2-{(S)-3-isopropyl-4-[(2-nitrophenyl)sulfonyl]-2-oxopiperazin-1-yl}propanoate

There total 5 articles about methyl (S)-3-(1H-indol-3-yl)-2-{(S)-3-isopropyl-4-[(2-nitrophenyl)sulfonyl]-2-oxopiperazin-1-yl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1613043-75-6
methyl (S)-3-(1H-indol-3-yl)-2-[(S)-3-methyl-2-(2-nitrophenylsulfonamido)butanamido]propanoate

: 106-93-4
ethylene dibromide

: 1613043-99-4
methyl (S)-3-(1H-indol-3-yl)-2-{(S)-3-isopropyl-4-[(2-nitrophenyl)sulfonyl]-2-oxopiperazin-1-yl}propanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 48h;
DOI:10.1002/ejoc.201301773

Reference yield:

: 13518-40-6
L-valine tert-butylester hydrochloride

: 1613043-99-4
methyl (S)-3-(1H-indol-3-yl)-2-{(S)-3-isopropyl-4-[(2-nitrophenyl)sulfonyl]-2-oxopiperazin-1-yl}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 20 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 24 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 48 h / 60 °C

With potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201301773

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1613043-99-4
methyl (S)-3-(1H-indol-3-yl)-2-{(S)-3-isopropyl-4-[(2-nitrophenyl)sulfonyl]-2-oxopiperazin-1-yl}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 20 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 24 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 48 h / 60 °C

With potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201301773