ethyl [2-(2,2-dimethylpropanoylamino)-6-methoxy-4-methylphenyl]oxoacetate

Base Information

Chemical Name:ethyl [2-(2,2-dimethylpropanoylamino)-6-methoxy-4-methylphenyl]oxoacetate
CAS No.:856893-62-4
Molecular Formula:C₁₇H₂₃NO₅
Molecular Weight:321.373
Hs Code.:

Synonyms:ethyl [2-(2,2-dimethylpropanoylamino)-6-methoxy-4-methylphenyl]oxoacetate

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Chemical Property of ethyl [2-(2,2-dimethylpropanoylamino)-6-methoxy-4-methylphenyl]oxoacetate

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Technology Process of ethyl [2-(2,2-dimethylpropanoylamino)-6-methoxy-4-methylphenyl]oxoacetate

There total 4 articles about ethyl [2-(2,2-dimethylpropanoylamino)-6-methoxy-4-methylphenyl]oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 856893-61-3
N-(3-methoxy-5-methylphenyl)-2,2-dimethylpropionamide

: 95-92-1
oxalic acid diethyl ester

: 856893-62-4
ethyl [2-(2,2-dimethylpropanoylamino)-6-methoxy-4-methylphenyl]oxoacetate

Guidance literature:: N-(3-methoxy-5-methylphenyl)-2,2-dimethylpropionamide; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at 0 ℃; for 2h;

oxalic acid diethyl ester; In ethanol; hexane; at -78 - 20 ℃; for 2.5h;
DOI:10.1021/ol050769m

Reference yield:

: 615-74-7
2-chloro-5-methylphenol

: 856893-62-4
ethyl [2-(2,2-dimethylpropanoylamino)-6-methoxy-4-methylphenyl]oxoacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / K₂CO₃ / acetone / 3.5 h / Heating

2.1: 58 percent / NH₃(liquid); Na; iron nitrate nonahydrate / acetone / 2 h / Heating

3.1: 94 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

4.1: TMEDA; n-BuLi / tetrahydrofuran; hexane / 2 h / 0 °C

4.2: 48 percent / ethanol; hexane / 2.5 h / -78 - 20 °C

With iron(II) nitrate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; ammonia; sodium; potassium carbonate; triethylamine; In tetrahydrofuran; hexane; dichloromethane; acetone;
DOI:10.1021/ol050769m

Reference yield:

: 66584-31-4
3-methoxy-5-methylphenylamine

: 856893-62-4
ethyl [2-(2,2-dimethylpropanoylamino)-6-methoxy-4-methylphenyl]oxoacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

2.1: TMEDA; n-BuLi / tetrahydrofuran; hexane / 2 h / 0 °C

2.2: 48 percent / ethanol; hexane / 2.5 h / -78 - 20 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol050769m