(S)-6-Benzyloxycarbonylamino-2-((R)-1-benzyloxycarbonyl-3-phenyl-propylamino)-hexanoic acid tert-butyl ester

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Chemical Name:(S)-6-Benzyloxycarbonylamino-2-((R)-1-benzyloxycarbonyl-3-phenyl-propylamino)-hexanoic acid tert-butyl ester
CAS No.:130275-82-0
Molecular Formula:C₃₅H₄₄N₂O₆
Molecular Weight:588.744
Hs Code.:

Synonyms:(S)-6-Benzyloxycarbonylamino-2-((R)-1-benzyloxycarbonyl-3-phenyl-propylamino)-hexanoic acid tert-butyl ester

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Chemical Property of (S)-6-Benzyloxycarbonylamino-2-((R)-1-benzyloxycarbonyl-3-phenyl-propylamino)-hexanoic acid tert-butyl ester

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Technology Process of (S)-6-Benzyloxycarbonylamino-2-((R)-1-benzyloxycarbonyl-3-phenyl-propylamino)-hexanoic acid tert-butyl ester

There total 3 articles about (S)-6-Benzyloxycarbonylamino-2-((R)-1-benzyloxycarbonyl-3-phenyl-propylamino)-hexanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 63628-63-7
Nε-benzyloxycarbonyl-L-lysine tert-butyl ester

: 112076-94-5
2-trifluoromethanesulfonyloxy-4-phenylbutyric acid benzyl ester

: 107832-07-5
N⁶-(benzyloxycarbonyl)-N²-<1(S)-(benzyloxycarbonyl)-3-phenylpropyl>-L-lysine tert-butyl ester

: 130275-82-0
(S)-6-Benzyloxycarbonylamino-2-((R)-1-benzyloxycarbonyl-3-phenyl-propylamino)-hexanoic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; 1.) RT, 1 h, 2.) reflux, 2.5 h;
DOI:10.1021/jm00105a066

Reference yield:

: 4263-93-8,111611-91-7
2-hydroxy-4-phenylbutanoic acid

: 130275-82-0
(S)-6-Benzyloxycarbonylamino-2-((R)-1-benzyloxycarbonyl-3-phenyl-propylamino)-hexanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 46 percent / triethylamine / ethyl acetate / 16 h / Heating

2: 1.) pyridine / 1.) dichloromethane, -22 deg C, 15 min, 2.) RT, 1 h

3: triethylamine / CH₂Cl₂ / 1.) RT, 1 h, 2.) reflux, 2.5 h

With pyridine; triethylamine; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00105a066

Reference yield:

: 109684-03-9
benzyl 2(R)-hydroxy-4-phenylbutyrate

: 130275-82-0
(S)-6-Benzyloxycarbonylamino-2-((R)-1-benzyloxycarbonyl-3-phenyl-propylamino)-hexanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) pyridine / 1.) dichloromethane, -22 deg C, 15 min, 2.) RT, 1 h

2: triethylamine / CH₂Cl₂ / 1.) RT, 1 h, 2.) reflux, 2.5 h

With pyridine; triethylamine; In dichloromethane;
DOI:10.1021/jm00105a066