(S)-ethyl 2-(N-(5-amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

Base Information

Chemical Name:(S)-ethyl 2-(N-(5-amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate
CAS No.:1333115-57-3
Molecular Formula:C₂₂H₂₇F₃N₂O₅S
Molecular Weight:488.528
Hs Code.:

Synonyms:(S)-ethyl 2-(N-(5-amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

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Chemical Property of (S)-ethyl 2-(N-(5-amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

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Technology Process of (S)-ethyl 2-(N-(5-amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

There total 8 articles about (S)-ethyl 2-(N-(5-amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333115-56-2
(R,E)-ethyl 2-(N-(4-cyano-1-phenylbut-3-en-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

: 1333115-57-3
(S)-ethyl 2-(N-(5-amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

Guidance literature:: With hydrogen; trifluoroacetic acid; platinum(IV) oxide; platinum on activated charcoal; In methanol; for 12h; under 2482.38 Torr;

Reference yield:

: 19901-50-9,51987-73-6,77119-84-7
methyl (2R)-2-(t-butoxycarbonylamino)-3-phenylpropionate

: 1333115-57-3
(S)-ethyl 2-(N-(5-amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / methanol

4.1: triethylamine / dichloromethane / 12 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

6.1: hydrogen; trifluoroacetic acid / platinum(IV) oxide; platinum on activated charcoal / methanol / 12 h / 2482.38 Torr

With hydrogenchloride; hydrogen; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; lithium chloride; platinum(IV) oxide; platinum on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 673-06-3,25191-15-5,658-69-5,67675-33-6
D-(R)-phenylalanine

: 1333115-57-3
(S)-ethyl 2-(N-(5-amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / 4 h / Reflux

2.1: sodium hydrogencarbonate / dichloromethane; water / 3 h / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere

3.2: 20 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / methanol

6.1: triethylamine / dichloromethane / 12 h / 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

8.1: hydrogen; trifluoroacetic acid / platinum(IV) oxide; platinum on activated charcoal / methanol / 12 h / 2482.38 Torr

With hydrogenchloride; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; lithium chloride; platinum(IV) oxide; platinum on activated charcoal; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;