6-bromo-1-(methoxy(pyridin-3-yl)methyl)-9-methyl-5-phenylpyrazolo[5,1-a]isoquinoline

Base Information

Chemical Name:6-bromo-1-(methoxy(pyridin-3-yl)methyl)-9-methyl-5-phenylpyrazolo[5,1-a]isoquinoline
CAS No.:1313199-90-4
Molecular Formula:C₂₅H₂₀BrN₃O
Molecular Weight:458.357
Hs Code.:

Synonyms:6-bromo-1-(methoxy(pyridin-3-yl)methyl)-9-methyl-5-phenylpyrazolo[5,1-a]isoquinoline

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Chemical Property of 6-bromo-1-(methoxy(pyridin-3-yl)methyl)-9-methyl-5-phenylpyrazolo[5,1-a]isoquinoline

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Technology Process of 6-bromo-1-(methoxy(pyridin-3-yl)methyl)-9-methyl-5-phenylpyrazolo[5,1-a]isoquinoline

There total 2 articles about 6-bromo-1-(methoxy(pyridin-3-yl)methyl)-9-methyl-5-phenylpyrazolo[5,1-a]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 28447-15-6,32986-65-5
trans-3-(3-pyridyl)acrolein

: C₂₃H₁₉BrN₂O₂S

: 1313199-90-4
6-bromo-1-(methoxy(pyridin-3-yl)methyl)-9-methyl-5-phenylpyrazolo[5,1-a]isoquinoline

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrachloromethane; at 50 ℃;
DOI:10.1055/s-0030-1259704

Reference yield:

: 1313200-11-1
C₂₃H₂₀N₂O₂S

: 1313199-90-4
6-bromo-1-(methoxy(pyridin-3-yl)methyl)-9-methyl-5-phenylpyrazolo[5,1-a]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: bromine / dichloromethane / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrachloromethane / 50 °C

With bromine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrachloromethane; dichloromethane;
DOI:10.1055/s-0030-1259704

Reference yield: 93.0%

: 1313199-90-4
6-bromo-1-(methoxy(pyridin-3-yl)methyl)-9-methyl-5-phenylpyrazolo[5,1-a]isoquinoline

: 98-80-6
phenylboronic acid

: 1313200-06-4
1-(methoxy(pyridin-3-yl)methyl)-9-methyl-5,6-diphenylpyrazolo[5,1-a]isoquinoline

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In water; N,N-dimethyl-formamide; at 50 ℃; Inert atmosphere;
DOI:10.1055/s-0030-1259704