2-(1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl)-4,5-dimethoxyphenyl methanesulfonate

Base Information

• Chemical Name: 2-(1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl)-4,5-dimethoxyphenyl methanesulfonate
• CAS No.: 332841-56-2
• Molecular Formula: C₃₁H₃₃NO₉S
• Molecular Weight: 595.67
• Mol file: 332841-56-2.mol

Synonyms:2-(1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl)-4,5-dimethoxyphenyl methanesulfonate

Chemical Property of 2-(1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl)-4,5-dimethoxyphenyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl)-4,5-dimethoxyphenyl methanesulfonate

There total 3 articles about 2-(1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl)-4,5-dimethoxyphenyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3.4-dihydroisoquinoline hydrochloride (5884-22-0) + Methanesulfonic acid 2-(2-bromo-acetyl)-4,5-dimethoxy-phenyl ester (332841-60-8) → 2-(1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl)-4,5-dimethoxyphenyl methanesulfonate (332841-56-2)

Guidance literature:

With sodium hydrogencarbonate; In acetonitrile; for 8h; Reflux;

DOI:10.1016/j.ejmech.2009.09.017

Reference yield:

2-hydroxy-4,5-dimethoxyacetophenone (20628-06-2) → 2-(1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl)-4,5-dimethoxyphenyl methanesulfonate (332841-56-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / Et₃N / CH₂Cl₂

2: 83 percent / benzyltrimethylammonium tribromide / CH₂Cl₂

3: 63 percent / K₂CO₃ / acetonitrile / Heating

With benzyltrimethylammonium tribromide; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(00)02222-X

Reference yield:

methanesulfonic acid 2-acetyl-4,5-dimethoxy-phenyl ester → 2-(1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl)-4,5-dimethoxyphenyl methanesulfonate (332841-56-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / benzyltrimethylammonium tribromide / CH₂Cl₂

2: 63 percent / K₂CO₃ / acetonitrile / Heating

With benzyltrimethylammonium tribromide; potassium carbonate; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(00)02222-X

upstream raw materials:

1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3.4-dihydroisoquinoline hydrochloride

Methanesulfonic acid 2-(2-bromo-acetyl)-4,5-dimethoxy-phenyl ester

2-hydroxy-4,5-dimethoxyacetophenone

Downstream raw materials:

3-formyl-2-(3'',4''-dimethoxy-2''-mesyloxyphenyl)-1-(3',4'-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline

14-(3,4-dimethoxyphenyl)-2,3,11,12-tetramethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

1-(3,4-dimethoxy-phenyl)-2-(2-hydroxy-4,5-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinoline-3-carbaldehyde