2-(4-bromo-2-fluorobenzoyl)-3-ethylamino-3-methylsulfanylacrylic acid ethyl ester

Base Information

Chemical Name:2-(4-bromo-2-fluorobenzoyl)-3-ethylamino-3-methylsulfanylacrylic acid ethyl ester
CAS No.:1204536-77-5
Molecular Formula:C₁₅H₁₇BrFNO₃S
Molecular Weight:390.273
Hs Code.:

Synonyms:2-(4-bromo-2-fluorobenzoyl)-3-ethylamino-3-methylsulfanylacrylic acid ethyl ester

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Chemical Property of 2-(4-bromo-2-fluorobenzoyl)-3-ethylamino-3-methylsulfanylacrylic acid ethyl ester

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Technology Process of 2-(4-bromo-2-fluorobenzoyl)-3-ethylamino-3-methylsulfanylacrylic acid ethyl ester

There total 1 articles about 2-(4-bromo-2-fluorobenzoyl)-3-ethylamino-3-methylsulfanylacrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1204536-76-4
2-(4-Bromo-2-fluorobenzoyl)-3,3-bismethylsulfanylacrylic Acid Ethyl Ester

: 75-04-7,85404-22-4
ethylamine

: 1204536-77-5
2-(4-bromo-2-fluorobenzoyl)-3-ethylamino-3-methylsulfanylacrylic acid ethyl ester

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 24h;

Reference yield:

: 1204536-77-5
2-(4-bromo-2-fluorobenzoyl)-3-ethylamino-3-methylsulfanylacrylic acid ethyl ester

: 1204536-79-7
7-(4-Aminophenyl)-1-ethyl-2-methylsulfanyl-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Ethyl Ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 16 h / Reflux; Inert atmosphere

With sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1204536-77-5
2-(4-bromo-2-fluorobenzoyl)-3-ethylamino-3-methylsulfanylacrylic acid ethyl ester

: 1204536-80-0
7-(4-Aminophenyl)-1-ethyl-4-oxo-2-(2-pyrrolidin-1-ylethylamino)-1,4-dihydroquinoline-3-carboxylic Acid (2-pyrrolidin-1-ylethyl)amide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 16 h / Reflux; Inert atmosphere

3: 16 h / 135 °C / Sealed tube

With sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;