2-(4-Bromo-2-fluorobenzoyl)-3,3-bismethylsulfanylacrylic Acid Ethyl Ester

Base Information

Chemical Name:2-(4-Bromo-2-fluorobenzoyl)-3,3-bismethylsulfanylacrylic Acid Ethyl Ester
CAS No.:1204536-76-4
Molecular Formula:C₁₄H₁₄BrFO₃S₂
Molecular Weight:393.298
Hs Code.:

Synonyms:2-(4-Bromo-2-fluorobenzoyl)-3,3-bismethylsulfanylacrylic Acid Ethyl Ester

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Chemical Property of 2-(4-Bromo-2-fluorobenzoyl)-3,3-bismethylsulfanylacrylic Acid Ethyl Ester

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Technology Process of 2-(4-Bromo-2-fluorobenzoyl)-3,3-bismethylsulfanylacrylic Acid Ethyl Ester

There total 1 articles about 2-(4-Bromo-2-fluorobenzoyl)-3,3-bismethylsulfanylacrylic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 75-15-0,12122-00-8
carbon disulfide

: 112704-80-0
ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate

: 74-88-4
methyl iodide

: 1204536-76-4
2-(4-Bromo-2-fluorobenzoyl)-3,3-bismethylsulfanylacrylic Acid Ethyl Ester

Guidance literature:: ethyl 3-(4-bromo-2-fluorophenyl)-3-oxopropanoate; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

carbon disulfide; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield: 55.0%

: 1204536-76-4
2-(4-Bromo-2-fluorobenzoyl)-3,3-bismethylsulfanylacrylic Acid Ethyl Ester

: 75-04-7,85404-22-4
ethylamine

: 1204536-77-5
2-(4-bromo-2-fluorobenzoyl)-3-ethylamino-3-methylsulfanylacrylic acid ethyl ester

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 24h;

Reference yield:

: 1204536-76-4
2-(4-Bromo-2-fluorobenzoyl)-3,3-bismethylsulfanylacrylic Acid Ethyl Ester

: 1204536-79-7
7-(4-Aminophenyl)-1-ethyl-2-methylsulfanyl-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Ethyl Ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 24 h / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 16 h / Reflux; Inert atmosphere

With sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;