tert-butyl (2R,5R,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)-propyl]-6-(4-methoxyphenyl)-4-methylhex-3-enoate

Base Information

Chemical Name:tert-butyl (2R,5R,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)-propyl]-6-(4-methoxyphenyl)-4-methylhex-3-enoate
CAS No.:1361407-67-1
Molecular Formula:C₃₂H₅₅NO₆Si
Molecular Weight:577.877
Hs Code.:

Synonyms:tert-butyl (2R,5R,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)-propyl]-6-(4-methoxyphenyl)-4-methylhex-3-enoate

Suppliers and Price of tert-butyl (2R,5R,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)-propyl]-6-(4-methoxyphenyl)-4-methylhex-3-enoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (2R,5R,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)-propyl]-6-(4-methoxyphenyl)-4-methylhex-3-enoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (2R,5R,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)-propyl]-6-(4-methoxyphenyl)-4-methylhex-3-enoate

There total 6 articles about tert-butyl (2R,5R,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)-propyl]-6-(4-methoxyphenyl)-4-methylhex-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361407-65-9
tert-butyl (E)-3-[(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-on-5-yl]prop-2-enoate

: 3-(tert-butyldimethylsilyloxy)-1-propyllithium

: 1361407-67-1
tert-butyl (2R,5R,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)-propyl]-6-(4-methoxyphenyl)-4-methylhex-3-enoate

: 1361407-75-1
tert-butyl (2S,5R,3Z)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)-propyl]-6-(4-methoxyphenyl)-4-methylhex-3-enoate

Guidance literature:: With copper(l) cyanide; lithium chloride; In tetrahydrofuran; diethyl ether; pentane; at -78 - 0 ℃; for 1h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/jm2016914

Reference yield:

: 1361407-60-4
(3R,4R)-4-[N-(tert-butoxycarbonyl)amino]-5-(4-methoxyphenyl)-3-methylpent-1-en-3-ol

: 1361407-67-1
tert-butyl (2R,5R,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)-propyl]-6-(4-methoxyphenyl)-4-methylhex-3-enoate

: 1361407-75-1
tert-butyl (2S,5R,3Z)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)-propyl]-6-(4-methoxyphenyl)-4-methylhex-3-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 °C / Inert atmosphere; Reflux

1.2: 2 h / 0 °C / Inert atmosphere

2.1: dimethylsulfide; ozone / ethyl acetate / 0.5 h / -78 - 0 °C

3.1: N-ethyl-N,N-diisopropylamine; lithium chloride / acetonitrile / 0.5 h / 0 °C / Inert atmosphere

3.2: 3.5 h / 0 °C / Inert atmosphere

4.1: copper(l) cyanide; lithium chloride / tetrahydrofuran; diethyl ether; pentane / 1 h / -78 - 0 °C / Inert atmosphere

With dimethylsulfide; copper(l) cyanide; sodium hydride; ozone; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; diethyl ether; ethyl acetate; acetonitrile; mineral oil; pentane; 3.1: Horner-Wadsworth-Emmons olefination / 3.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm2016914

Reference yield:

: 1361407-63-7
(4R,5R)-N-(tert-butoxycarbonyl)-5-ethenyl-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-one

: 1361407-67-1
tert-butyl (2R,5R,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)-propyl]-6-(4-methoxyphenyl)-4-methylhex-3-enoate

: 1361407-75-1
tert-butyl (2S,5R,3Z)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)-propyl]-6-(4-methoxyphenyl)-4-methylhex-3-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylsulfide; ozone / ethyl acetate / 0.5 h / -78 - 0 °C

2.1: N-ethyl-N,N-diisopropylamine; lithium chloride / acetonitrile / 0.5 h / 0 °C / Inert atmosphere

2.2: 3.5 h / 0 °C / Inert atmosphere

3.1: copper(l) cyanide; lithium chloride / tetrahydrofuran; diethyl ether; pentane / 1 h / -78 - 0 °C / Inert atmosphere

With dimethylsulfide; copper(l) cyanide; ozone; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; diethyl ether; ethyl acetate; acetonitrile; pentane; 2.1: Horner-Wadsworth-Emmons olefination / 2.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm2016914