1-{[5-(2,4-Dichlorophenyl)-4-(4-hydroxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

Base Information

Chemical Name:1-{[5-(2,4-Dichlorophenyl)-4-(4-hydroxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide
CAS No.:1207203-44-8
Molecular Formula:C₂₉H₂₄Cl₂N₂O₃S
Molecular Weight:551.493
Hs Code.:

Synonyms:1-{[5-(2,4-Dichlorophenyl)-4-(4-hydroxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

Suppliers and Price of 1-{[5-(2,4-Dichlorophenyl)-4-(4-hydroxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-{[5-(2,4-Dichlorophenyl)-4-(4-hydroxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-{[5-(2,4-Dichlorophenyl)-4-(4-hydroxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

There total 11 articles about 1-{[5-(2,4-Dichlorophenyl)-4-(4-hydroxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56243-25-5
1-benzyl-4-cyano-4-phenylpiperidine

: 1207203-44-8
1-{[5-(2,4-Dichlorophenyl)-4-(4-hydroxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sulfuric acid / 1 h / 100 °C

1.2: Cooling with ice

2.1: cyclohexa-1,3-diene / palladium 10% on activated carbon / methanol / 6 h / Reflux

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 3 h / 20 °C

4.1: boron tribromide / dichloromethane / 3 h / 20 °C / Cooling with ice

With sulfuric acid; water; boron tribromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; cyclohexa-1,3-diene; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

: 1207203-43-7
1-{[5-(2,4-Dichlorophenyl)-4-(4-methoxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

: 1207203-44-8
1-{[5-(2,4-Dichlorophenyl)-4-(4-hydroxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

Guidance literature:: 1-{[5-(2,4-Dichlorophenyl)-4-(4-methoxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide; With boron tribromide; In dichloromethane; at 20 ℃; for 3h; Cooling with ice;

With water; In dichloromethane;

Reference yield:

: 59084-07-0
1-benzyl-4-phenyl-piperidine-4-carboxylic acid amide; hydrochloride

: 1207203-44-8
1-{[5-(2,4-Dichlorophenyl)-4-(4-hydroxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: cyclohexa-1,3-diene / palladium 10% on activated carbon / methanol / 6 h / Reflux

2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 3 h / 20 °C

3: boron tribromide / dichloromethane / 3 h / 20 °C / Cooling with ice

With boron tribromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; cyclohexa-1,3-diene; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;