biphenyl-2-carboxylic acid [2-hydroxy-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenyl]-amide

Base Information

Chemical Name:biphenyl-2-carboxylic acid [2-hydroxy-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenyl]-amide
CAS No.:190276-13-2
Molecular Formula:C₂₈H₂₄N₂O₃S
Molecular Weight:468.576
Hs Code.:

biphenyl-2-carboxylic acid [2-hydroxy-4-(5,6,7,8-tetrahydro-thieno[3,2-<i>b</i>]azepine-4-carbonyl)-phenyl]-amide

Synonyms:biphenyl-2-carboxylic acid [2-hydroxy-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenyl]-amide

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Chemical Property of biphenyl-2-carboxylic acid [2-hydroxy-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenyl]-amide

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Technology Process of biphenyl-2-carboxylic acid [2-hydroxy-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenyl]-amide

There total 7 articles about biphenyl-2-carboxylic acid [2-hydroxy-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5081-36-7
3-methoxy-4-nitrobenzoic acid

: 190276-13-2
biphenyl-2-carboxylic acid [2-hydroxy-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / CHCl₃ / Heating

2: Et₃N / CHCl₃ / 20 °C

3: H₂ / Pd/C

4: Et₃N / 20 °C

5: BBr₃

With thionyl chloride; hydrogen; boron tribromide; triethylamine; palladium on activated charcoal; In chloroform;
DOI:10.1021/jm030287l

Reference yield:

: 67579-92-4
3-methoxy-4-nitrobenzoic acid chloride

: 190276-13-2
biphenyl-2-carboxylic acid [2-hydroxy-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CHCl₃ / 20 °C

2: H₂ / Pd/C

3: Et₃N / 20 °C

4: BBr₃

With hydrogen; boron tribromide; triethylamine; palladium on activated charcoal; In chloroform;
DOI:10.1021/jm030287l

Reference yield:

: 190276-75-6
(3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone

: 190276-13-2
biphenyl-2-carboxylic acid [2-hydroxy-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C

2: Et₃N / 20 °C

3: BBr₃

With hydrogen; boron tribromide; triethylamine; palladium on activated charcoal;
DOI:10.1021/jm030287l