4-(2-(4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-1H-pyrazol-1-yl)ethyl)morpholine

Base Information

Chemical Name:4-(2-(4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-1H-pyrazol-1-yl)ethyl)morpholine
CAS No.:1196546-56-1
Molecular Formula:C₂₅H₂₇F₂N₇O
Molecular Weight:479.532
Hs Code.:

Synonyms:4-(2-(4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-1H-pyrazol-1-yl)ethyl)morpholine

Suppliers and Price of 4-(2-(4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-1H-pyrazol-1-yl)ethyl)morpholine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(2-(4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-1H-pyrazol-1-yl)ethyl)morpholine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(2-(4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-1H-pyrazol-1-yl)ethyl)morpholine

There total 9 articles about 4-(2-(4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-1H-pyrazol-1-yl)ethyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1196552-01-8
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(1H-pyrazol-4-yl)imidazo[1,2-b]pyridazine

: 3647-69-6
4-(2-chloroethyl)morpholine hydrochride

: 1196546-56-1
4-(2-(4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-1H-pyrazol-1-yl)ethyl)morpholine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: (2,5-difluorophenyl)magnesium chloride

: 1196546-56-1
4-(2-(4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-1H-pyrazol-1-yl)ethyl)morpholine

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: hydrogenchloride; water / methanol / 6 h / 70 °C

3.1: sodium tetrahydroborate / ethanol / 20 °C

4.1: potassium fluoride / dimethyl sulfoxide / 130 °C

5.1: water; sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.2 h / 150 °C / Microwave irradiation

6.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; potassium fluoride; sodium tetrahydroborate; water; sodium carbonate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 399-94-0
2-bromo-1,4-difluorobenzene

: 1196546-56-1
4-(2-(4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-1H-pyrazol-1-yl)ethyl)morpholine

Guidance literature:: Multi-step reaction with 7 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -78 - -20 °C / Inert atmosphere

2.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 20 °C

3.1: hydrogenchloride; water / methanol / 6 h / 70 °C

4.1: sodium tetrahydroborate / ethanol / 20 °C

5.1: potassium fluoride / dimethyl sulfoxide / 130 °C

6.1: water; sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.2 h / 150 °C / Microwave irradiation

7.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; potassium fluoride; sodium tetrahydroborate; water; isopropylmagnesium chloride; sodium carbonate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;