3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester

Base Information

• Chemical Name: 3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester
• CAS No.: 134390-45-7
• Molecular Formula: C₁₁H₁₂O₅
• Molecular Weight: 224.213
• Mol file: 134390-45-7.mol

Synonyms:3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester

Chemical Property of 3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester

There total 15 articles about 3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

phenylpropynoic acid ethyl ester (2216-94-6) → 3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester (134390-45-7)

Guidance literature:

phenylpropynoic acid ethyl ester; With 2,6-dichloropyridine N-oxide; In dichloromethane; at 20 ℃; for 1h; Green chemistry;

With water; Reagent/catalyst; Solvent; Temperature; Time; Green chemistry;

DOI:10.1016/j.tetlet.2021.152953

Reference yield: 88.0%

phenylpropynoic acid ethyl ester (2216-94-6) + acetonitrile (75-05-8,26809-02-9) → ethyl 2-methyl-5-phenyl-4-oxazolecarboxylate (92029-40-8) + 3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester (134390-45-7)

Guidance literature:

With 2-chloropyridine-N-oxide; chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver trifluoromethanesulfonate; In neat (no solvent); at 80 ℃; for 6h; Reagent/catalyst; Temperature;

DOI:10.1002/adsc.201900097

Reference yield: 77.0%

nitrobenzene (98-95-3,26969-40-4) + phenylpropynoic acid ethyl ester (2216-94-6) → ethyl 2,3-dioxo-3-phenylpropanoate (3885-45-8) + (E)-N-((E)-1-ethoxy-1-oxo-3-phenyl-3-(phenylimino)propan-2-ylidene)anilineoxide + 3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester (134390-45-7)

Guidance literature:

With 2-(di-tert-butylphosphino)-1,1'-biphenylgold(I) chloride; silver(I) triflimide; In 1,2-dichloro-ethane; at 25 ℃; for 6h; Reagent/catalyst; Solvent; Inert atmosphere;

DOI:10.1039/c4cc06962e

upstream raw materials:

methanol

ethyl 3-oxo-3-phenylpropionate

ethyl 2-hydroxy-3-phenyl-3-oxopropanoate

ethyl (2E)-3-diethylamino-3-phenylprop-2-enoate