ethyl (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

Base Information

Chemical Name:ethyl (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate
CAS No.:1365889-11-7
Molecular Formula:C₂₈H₂₄ClFN₂O₂
Molecular Weight:474.962
Hs Code.:

Synonyms:ethyl (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

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Chemical Property of ethyl (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

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Technology Process of ethyl (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

There total 6 articles about ethyl (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365889-10-6
(E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

: 1365889-11-7
ethyl (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

Guidance literature:: With hydrogenchloride; In ethanol; water; at 70 ℃;
DOI:10.1021/acs.jmedchem.5b00054

Reference yield:

: 15164-44-0
p-(iodophenyl)carboxaldehyde

: 1365889-11-7
ethyl (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; bis-triphenylphosphine-palladium(II) chloride / 2-methyltetrahydrofuran / 26 h / 20 - 40 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide / water / 7 h / 75 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 20 °C

4: hydrogenchloride / water; ethanol / 70 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; potassium hydroxide; In 2-methyltetrahydrofuran; ethanol; water; acetonitrile;
DOI:10.1021/acs.jmedchem.5b00054

Reference yield:

: C₂₉H₃₅BN₂O₄

: 1365889-11-7
ethyl (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide / water / 7 h / 75 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 20 °C

3: hydrogenchloride / water; ethanol / 70 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; potassium hydroxide; In ethanol; water; acetonitrile;
DOI:10.1021/acs.jmedchem.5b00054