(E)-4-(2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

Base Information

Chemical Name:(E)-4-(2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde
CAS No.:1365889-09-3
Molecular Formula:C₂₉H₂₆ClFN₂O₂
Molecular Weight:488.989
Hs Code.:

Synonyms:(E)-4-(2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

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Chemical Property of (E)-4-(2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

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Technology Process of (E)-4-(2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

There total 10 articles about (E)-4-(2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365889-00-4
5-(but-1-yn-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

: 101335-11-9
2-chloro-4-fluoro-1-iodobenzene

: 15164-44-0
p-(iodophenyl)carboxaldehyde

: 1365889-09-3
(E)-4-(2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

: (Z)-4-(2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

Guidance literature:: 5-(but-1-yn-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; With bis(pinacol)diborane; tetrakis(triphenylphosphine)platinum; In 2-methyltetrahydrofuran; at 83 ℃; for 5h; Inert atmosphere;

p-(iodophenyl)carboxaldehyde; With caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 2-methyltetrahydrofuran; water; at 4 - 20 ℃; Inert atmosphere;

2-chloro-4-fluoro-1-iodobenzene; In 2-methyltetrahydrofuran; water; at 75 ℃; for 7h; Inert atmosphere;

Reference yield:

: (Z)-4-(1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-1-en-1-yl)benzaldehyde

: 101335-11-9
2-chloro-4-fluoro-1-iodobenzene

: 1365889-09-3
(E)-4-(2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

Guidance literature:: With palladium diacetate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; water; at 67 ℃;

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1365889-09-3
(E)-4-(2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

: (Z)-4-(2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 48 h / 20 °C / Inert atmosphere

2.1: caesium carbonate; copper(l) iodide / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / ISOPROPYLAMIDE / 5 h / 80 °C / Inert atmosphere

3.1: bis(pinacol)diborane / tetrakis(triphenylphosphine)platinum / 2-methyltetrahydrofuran / 5 h / 83 °C / Inert atmosphere

3.2: 4 - 20 °C / Inert atmosphere

3.3: 7 h / 75 °C / Inert atmosphere

With copper(l) iodide; pyridinium p-toluenesulfonate; caesium carbonate; bis(pinacol)diborane; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine)platinum; palladium diacetate; In 2-methyltetrahydrofuran; dichloromethane; ISOPROPYLAMIDE;