Technology Process of 7-[5-(2-dimethylaminoethyl)thiazol-2-ylamino]-1-ethyl-3-phenyl-1H-[1,6]naphthyridin-2-one
There total 10 articles about 7-[5-(2-dimethylaminoethyl)thiazol-2-ylamino]-1-ethyl-3-phenyl-1H-[1,6]naphthyridin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane;
at 130 ℃;
for 3h;
Inert atmosphere;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tetrahydrofuran / 16.5 h / 0 - 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C
3.1: Dess-Martin periodane / tetrahydrofuran / 5 h / 0 - 20 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 100 °C
5.1: acetic anhydride / 2 h / 120 °C
5.2: 1 h / 80 °C
6.1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium carbonate / 1,4-dioxane / 3 h / 130 °C / Inert atmosphere; Microwave irradiation
With
tris-(dibenzylideneacetone)dipalladium(0); lithium aluminium tetrahydride; acetic anhydride; sodium carbonate; potassium carbonate; Dess-Martin periodane; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C
2.1: Dess-Martin periodane / tetrahydrofuran / 5 h / 0 - 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 100 °C
4.1: acetic anhydride / 2 h / 120 °C
4.2: 1 h / 80 °C
5.1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium carbonate / 1,4-dioxane / 3 h / 130 °C / Inert atmosphere; Microwave irradiation
With
tris-(dibenzylideneacetone)dipalladium(0); lithium aluminium tetrahydride; acetic anhydride; sodium carbonate; potassium carbonate; Dess-Martin periodane; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;