5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide

Base Information

Chemical Name:5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide
CAS No.:1310805-76-5
Molecular Formula:C₂₄H₂₅N₇O₅
Molecular Weight:491.506
Hs Code.:

Synonyms:5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide

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Chemical Property of 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide

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Technology Process of 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide

There total 4 articles about 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310807-56-7
ethyl 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-1,2,4-oxadiazole-3-carboxylate

: 124-40-3
dimethyl amine

: 1310805-76-5
5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at 20 ℃; for 3h; Inert atmosphere; Cooling with ice;

Reference yield:

: 453566-94-4
5-fluoropyridine-2-carboxylic acid hydrochloride

: 1310805-76-5
5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h

2: dichloromethane / 0.5 h / Cooling with ice

3: toluene-4-sulfonic acid / 1-methyl-pyrrolidin-2-one / 2 h / 130 °C / Cooling with ice

4: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / 60 - 80 °C

5: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Cooling with ice

With oxalyl dichloride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1310807-55-6
ethyl 5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazole-3-carboxylate

: 1310805-76-5
5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / 60 - 80 °C

2: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Cooling with ice

With diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;