(2S)-1-{(4S,6R)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}propan-2-ol

Base Information

Chemical Name:(2S)-1-{(4S,6R)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}propan-2-ol
CAS No.:876068-24-5
Molecular Formula:C₁₈H₂₈O₄
Molecular Weight:308.418
Hs Code.:

Synonyms:(2S)-1-{(4S,6R)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}propan-2-ol

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Chemical Property of (2S)-1-{(4S,6R)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}propan-2-ol

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Technology Process of (2S)-1-{(4S,6R)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}propan-2-ol

There total 14 articles about (2S)-1-{(4S,6R)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 853923-32-7
(4R,6R)-4-(2-Benzyloxy-ethyl)-2,2-dimethyl-6-oxiranylmethyl-[1,3]dioxane

: 876068-24-5
(2S)-1-{(4S,6R)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}propan-2-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.tetlet.2005.03.202

Reference yield: 89.0%

: 1173106-19-8
1-[(4R,6R)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]propan-2-one

: 876068-24-5
(2S)-1-{(4S,6R)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}propan-2-ol

Guidance literature:: With lithium aluminium tetrahydride; lithium iodide; In diethyl ether; at -100 - 20 ℃; Inert atmosphere;
DOI:10.1002/hlca.200800355

Reference yield:

: 853923-29-2
(R)-8-Benzyloxy-6-hydroxy-oct-1-en-4-one

: 876068-24-5
(2S)-1-{(4S,6R)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 75 percent / BEt₂OMe; NaBH₄ / tetrahydrofuran

2.1: 94 percent / PTSA / dimethylsulfoxide

3.1: oxone; NaHCO₃; EDTA / acetone

3.2: 43 percent / H₂O; (R,R)-(salen)Co(III)(OAc)

4.1: 89 percent / LAH / tetrahydrofuran / 20 °C

With Oxone; sodium tetrahydroborate; lithium aluminium tetrahydride; ethylenediaminetetraacetic acid; diethyl methoxy borane; sodium hydrogencarbonate; toluene-4-sulfonic acid; In tetrahydrofuran; dimethyl sulfoxide; acetone;
DOI:10.1016/j.tetlet.2005.03.202