Technology Process of (4R,5S)-4-(S)-1-(benzyloxy)-2-((4-methoxybenzyloxy)ethyl)-5-(iodomethyl)-2,2-dimethyl-1,3-dioxolane
There total 6 articles about (4R,5S)-4-(S)-1-(benzyloxy)-2-((4-methoxybenzyloxy)ethyl)-5-(iodomethyl)-2,2-dimethyl-1,3-dioxolane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1H-imidazole; iodine; triphenylphosphine;
In
diethyl ether; acetonitrile;
at 0 - 20 ℃;
for 2h;
DOI:10.1016/j.tetlet.2012.12.114
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: di(n-butyl)tin oxide / toluene / 8 h / Reflux
1.2: 12 h / Reflux
2.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 8 h / 0 - 20 °C
3.1: periodic acid / ethyl acetate / 1 h / 0 - 20 °C
4.1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C
5.1: iodine; triphenylphosphine; 1H-imidazole / acetonitrile; diethyl ether / 2 h / 0 - 20 °C
With
1H-imidazole; sodium tetrahydroborate; iodine; tetra-(n-butyl)ammonium iodide; sodium hydride; di(n-butyl)tin oxide; periodic acid; triphenylphosphine;
In
tetrahydrofuran; methanol; diethyl ether; ethyl acetate; toluene; acetonitrile;
DOI:10.1016/j.tetlet.2012.12.114
-
-
38145-93-6,58846-25-6,73745-56-9
(S)-1-((4R,4'R,5R)-2,2,2',2'-tetramethyl-4,4'-bi(1,3-dioxolan)-5-yl)ethane-1,2-diol
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: di(n-butyl)tin oxide / toluene / 8 h / Reflux
1.2: 12 h / Reflux
2.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 8 h / 0 - 20 °C
3.1: periodic acid / ethyl acetate / 1 h / 0 - 20 °C
4.1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C
5.1: iodine; triphenylphosphine; 1H-imidazole / acetonitrile; diethyl ether / 2 h / 0 - 20 °C
With
1H-imidazole; sodium tetrahydroborate; iodine; tetra-(n-butyl)ammonium iodide; sodium hydride; di(n-butyl)tin oxide; periodic acid; triphenylphosphine;
In
tetrahydrofuran; methanol; diethyl ether; ethyl acetate; toluene; acetonitrile;
DOI:10.1016/j.tetlet.2012.12.114