2-Methyl-1-(trifluoromethyl)-1H-benzimidazole

Base Information

Chemical Name:2-Methyl-1-(trifluoromethyl)-1H-benzimidazole
CAS No.:328406-17-3
Molecular Formula:C₉H₇F₃N₂
Molecular Weight:200.163
Hs Code.:
DSSTox Substance ID:DTXSID80573368
Wikidata:Q82462084
Mol file:328406-17-3.mol

Synonyms:328406-17-3;2-METHYL-1-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE;1H-Benzimidazole,2-methyl-1-(trifluoromethyl)-(9CI);DTXSID80573368;AKOS025312326;2-methyl-1-(trifluoromethyl)benzimidazole;2-Methyl-1-(trifluoromethyl)-1H-benzo[d]imidazole

Suppliers and Price of 2-Methyl-1-(trifluoromethyl)-1H-benzimidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
2-Methyl-1-(trifluoromethyl)-1H-benzimidazole
1 g
$ 595.00

American Custom Chemicals Corporation
2-METHYL-1-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE 95.00%
1G
$ 1264.73

Total 8 raw suppliers

Chemical Property of 2-Methyl-1-(trifluoromethyl)-1H-benzimidazole

Chemical Property:

Vapor Pressure:0.0903mmHg at 25°C
Refractive Index:1.527
Boiling Point:232.3°C at 760 mmHg
PKA:3.04±0.10(Predicted)
Flash Point:94.3°C
PSA：17.82000
Density:1.34g/cm³
LogP:2.82100
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:200.05613272
Heavy Atom Count:14
Complexity:217

Purity/Quality:

97% ^*data from raw suppliers

2-Methyl-1-(trifluoromethyl)-1H-benzimidazole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC2=CC=CC=C2N1C(F)(F)F

Technology Process of 2-Methyl-1-(trifluoromethyl)-1H-benzimidazole

There total 2 articles about 2-Methyl-1-(trifluoromethyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 273405-42-8
1-Bromodifluoromethyl-2-methylbenzimidazole

: 84941-16-2
1-(difluoromethyl)-2-methyl-1H-benzo[d]imidazole

: 328406-17-3
2-Methyl-1-trifluoromethylbenzimidazole

Guidance literature:: With tetramethylammonium fluoride; In 1,2-dimethoxyethane; for 5h; Heating;
DOI:10.1016/S0022-1139(00)00321-3

Reference yield:

: 615-15-6
2-Methyl-1H-benzimidazole

: 328406-17-3
2-Methyl-1-trifluoromethylbenzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH; Zn / acetonitrile / 3 h / -10 - -5 °C

1.2: 76 percent / acetonitrile / 16 h / -15 - 20 °C

2.1: 40 percent / Me₄NF / 1,2-dimethoxy-ethane / 5 h / Heating

With tetramethylammonium fluoride; sodium hydride; zinc; In 1,2-dimethoxyethane; acetonitrile;
DOI:10.1016/S0022-1139(00)00321-3