84941-16-2

Basic information

• Product Name: 1H-Benzimidazole,1-(difluoromethyl)-2-methyl-(9CI)
• Synonyms: 1H-Benzimidazole,1-(difluoromethyl)-2-methyl-(9CI);1-Difluoromethyl-2-methyl-benzimidazole;1H-Benzimidazole, 1-(difluoromethyl)-2-methyl-
• CAS NO: 84941-16-2
• Molecular Formula: C₉H₈F₂N₂
• Molecular Weight: 182.172
• Product Categories: BENZIMIDAZOLE
• Mol File: 84941-16-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 269.1 °C at 760 mmHg
• Flash Point: 116.5 °C
• Appearance: /
• Density: 1.29 g/cm³
• Vapor Pressure: 0.0123mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: 1H-Benzimidazole,1-(difluoromethyl)-2-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,1-(difluoromethyl)-2-methyl-(9CI)(84941-16-2)
• EPA Substance Registry System: 1H-Benzimidazole,1-(difluoromethyl)-2-methyl-(9CI)(84941-16-2)

Safety Data

• Hazardous Substances Data: 84941-16-2(Hazardous Substances Data)

Usage

General Description

1H-Benzimidazole, 1-(difluoromethyl)-2-methyl-(9CI) is a chemical compound with the molecular formula C9H8F2N2. It is a derivative of benzimidazole, containing a difluoromethyl substituent at the 1-position and a methyl group at the 2-position. 1H-Benzimidazole,1-(difluoromethyl)-2-methyl-(9CI) has the potential for various industrial and pharmaceutical applications due to its unique chemical structure and properties. It is important to handle this compound with care and adhere to proper safety protocols when working with it in laboratory or industrial settings.

InChI:InChI=1/C9H8F2N2/c1-6-12-7-4-2-3-5-8(7)13(6)9(10)11/h2-5,9H,1H3

Upstream product

• 615-15-6 2-Methyl-1H-benzimidazole 
• 1670-14-0 benzamidine monohydrochloride 
• 1895-39-2 sodium chlorodifluoroacetate 
• 273405-42-8 1-Bromodifluoromethyl-2-methylbenzimidazole 
• 2923-18-4 sodium 2,2,2-trifluoroacetate 
• 41253-31-0 Sodium salt 2-methylbenzimidazole 
• 75-45-6 Chlorodifluoromethane 
• 65094-22-6 diethyl (bromodifluoromethyl)phosphonate 

Relevant articles and documents

1-DIFLUOROMETHYLBENZIMIDAZOLES

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N-Difluoromethylation of imidazoles and pyrazoles using BrCF2PO(OEt)2 under mild condition

A simple and efficient protocol for the direct N-difluoromethylation of imidazoles and pyrazoles has been developed. The reaction makes use of commercially available, non-ozone-depleting and easy handling BrCF2PO(OEt)2 as difluorocarbene precursor, and provides a cost-efficient and environmentally benign access to some difluoromethylated biologically relevant molecules.

Reactions of some nitrogen heterocycles with chlorodifluoromethane under conditions of phase-transfer catalysis

Aromatic heterocyclic compounds containing one to four nitrogen atoms react with chlorodifluoromethane in the presence of concentrated aqueous sodium hydroxide and a catalyst, benzyltriethylammonium chloride (TEBAC) in dichloromethane or THF (phase-transfer catalysis, PTC) with formation of N-difluoromethyl substituted derivatives. The process takes place by reaction of N-anions from these heterocycles with difluorocarbene and protonation of difluoromethyl anions thus formed.