2-phenyl-N-(tosylmethyl)-1,2,3,4-tetrahydroisoquinoline-1-carbohydrazide

Base Information

• Chemical Name: 2-phenyl-N-(tosylmethyl)-1,2,3,4-tetrahydroisoquinoline-1-carbohydrazide
• CAS No.: 1361098-19-2
• Molecular Formula: C₂₃H₂₂N₂O
• Molecular Weight: 342.44
• Mol file: 1361098-19-2.mol

Synonyms:2-phenyl-N-(tosylmethyl)-1,2,3,4-tetrahydroisoquinoline-1-carbohydrazide

Chemical Property of 2-phenyl-N-(tosylmethyl)-1,2,3,4-tetrahydroisoquinoline-1-carbohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenyl-N-(tosylmethyl)-1,2,3,4-tetrahydroisoquinoline-1-carbohydrazide

There total 5 articles about 2-phenyl-N-(tosylmethyl)-1,2,3,4-tetrahydroisoquinoline-1-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N-benzyl-N-(1,3-dioxoisoindolin-2-yl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline-1-carboxamide → 2-phenyl-N-(tosylmethyl)-1,2,3,4-tetrahydroisoquinoline-1-carbohydrazide (1361098-19-2)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 24h;

DOI:10.1021/acs.joc.8b01868

Reference yield: 68.0%

2-phenyl-1,2,3,4-tetrahydroisoquinoline (3340-78-1) + Benzyl isocyanide (88333-03-3,10340-91-7) → 2-phenyl-N-(tosylmethyl)-1,2,3,4-tetrahydroisoquinoline-1-carbohydrazide (1361098-19-2)

Guidance literature:

With copper(II) choride dihydrate; oxygen; In N,N-dimethyl-formamide; at 20 ℃; for 168h;

DOI:10.1021/ja211697s

Reference yield:

iodobenzene (591-50-4) → 2-phenyl-N-(tosylmethyl)-1,2,3,4-tetrahydroisoquinoline-1-carbohydrazide (1361098-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; potassium phosphate / isopropyl alcohol; ethylene glycol / 90 °C / Inert atmosphere

2: diethylazodicarboxylate; succinic acid / dichloromethane / 6 h / 20 °C

With potassium phosphate; copper(l) iodide; succinic acid; diethylazodicarboxylate; In dichloromethane; ethylene glycol; isopropyl alcohol; 2: |Ugi Condensation;

DOI:10.1002/ejoc.201701323

upstream raw materials:

2-phenyl-1,2,3,4-tetrahydroisoquinoline

Benzyl isocyanide

iodobenzene

1,2,3,4-tetrahydroisoquinoline